Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPA3 | P15088 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ECE1 | P42892 | 1/20 | 0.46 |
| ▸ | MME | P08473 | 3/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6208838 | 1.00 | CPA3 (0.48) | CPA3FOLH1LMNAECE1MME | |
| SCHEMBL7315216 | 0.87 | ECE1 (0.49) | CPA3LMNAECE1TBXAS1ADAMTS4 | |
| Hydrochloric Acid SCHEMBL7854941 | 0.86 | ECE1 (0.48) | LMNAECE1TBXAS1ADAMTS4 | |
| SCHEMBL7313773 | 0.81 | CPA3 (0.52) | CPA3FOLH1MMELTA4H | |
| SCHEMBL7315467 | 0.81 | CPA3 (0.52) | CPA3FOLH1MMELTA4H | |
| SCHEMBL7333784 | 0.81 | CPA3 (0.52) | CPA3FOLH1MMELTA4H | |
| SCHEMBL7323948 | 0.81 | CPA3 (0.52) | CPA3FOLH1MMELTA4H | |
| SCHEMBL6208732 | 0.79 | CPA3 (0.50) | CPA3FOLH1MMETSHRLTA4H | |
| SCHEMBL6208734 | 0.79 | CPA3 (0.50) | CPA3FOLH1MMETSHRLTA4H | |
| SCHEMBL9067585 | 0.77 | HTT (0.39) | LMNATBXAS1GAATSHRADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0883612-B1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE (ACE/NEP) INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 2005-02-23 | — | — | EP | claimed |
| EP-0883612-B1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE (ACE/NEP) INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 2005-02-23 | — | — | EP | disclosed |
| US-6166051-A | Thiol derivatives with metallopeptidase (ACE/NEP) inhibitory activity | ZAMBON GROUP S.P.A. (IT) | 2000-12-26 | — | — | US | disclosed |
| EP-0883612-A1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE (ACE/NEP) INHIBITORY ACTIVITY | ZAMBON GROUP S.p.A. (IT) | 1998-12-16 | — | — | EP | disclosed |
| WO-1997024341-A1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE (ACE/NEP) INHIBITORY ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 1997-07-10 | — | — | WO | disclosed |