Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 2/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | CPA3 | P15088 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7854941 | 0.99 | ECE1 (0.48) | ECE1ADAMTS4LMNACAPN1CTSL | |
| SCHEMBL7323948 | 0.89 | CPA3 (0.52) | CPA3 | |
| SCHEMBL7313773 | 0.89 | CPA3 (0.52) | CPA3 | |
| SCHEMBL7333784 | 0.89 | CPA3 (0.52) | CPA3 | |
| SCHEMBL7315467 | 0.89 | CPA3 (0.52) | CPA3 | |
| SCHEMBL6208838 | 0.87 | CPA3 (0.48) | ECE1ADAMTS4LMNATBXAS1CPA3 | |
| SCHEMBL6208840 | 0.87 | CPA3 (0.48) | ECE1ADAMTS4LMNATBXAS1CPA3 | |
| SCHEMBL7312449 | 0.80 | CPA3 (0.43) | CPA3 | |
| SCHEMBL7321606 | 0.80 | PTGES (0.47) | LMNA | |
| SCHEMBL7597454 | 0.79 | HSD17B10 (0.47) | ECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | claimed |
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | disclosed |
| US-5760241-A | ANGIOTENSIN CONVERTING ENZYME AND ENKEPHALINASE INHIBITORS; CARDIOVASCULAR DISORDERS | ZAMBON GROUP S.P.A. (IT) | 1998-06-02 | — | — | US | disclosed |