Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPA3 | P15088 | 1/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.52 |
| ▸ | MME | P08473 | 6/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333784 | 1.00 | CPA3 (0.52) | CPA3FOLH1MMELTA4HGPR88 | |
| SCHEMBL7313773 | 1.00 | CPA3 (0.52) | CPA3FOLH1MMELTA4HGPR88 | |
| SCHEMBL7323948 | 1.00 | CPA3 (0.52) | CPA3FOLH1MMELTA4HGPR88 | |
| SCHEMBL7312449 | 0.90 | CPA3 (0.43) | CPA3FOLH1MMEACE | |
| SCHEMBL7315216 | 0.89 | ECE1 (0.49) | CPA3 | |
| Hydrochloric Acid SCHEMBL7854941 | 0.88 | ECE1 (0.48) | — | |
| SCHEMBL7321606 | 0.87 | PTGES (0.47) | FOLH1ACE | |
| SCHEMBL7310028 | 0.85 | MME (0.50) | MMEGPR88ACE | |
| SCHEMBL7338879 | 0.85 | MME (0.50) | MMEGPR88ACE | |
| SCHEMBL7322272 | 0.84 | MEN1 (0.36) | CPA3FOLH1MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0805817-B1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 2001-08-16 | — | — | EP | disclosed |
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | disclosed |