Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 5/20 | 0.36 |
| ▸ | MMP13 | P45452 | 4/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | MMP7 | P09237 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP8 | P22894 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | MMP10 | P09238 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | MGAT1 | P26572 | 1/20 | 0.34 |
| ▸ | MGAT3 | Q09327 | 1/20 | 0.34 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6210006 | 0.74 | MMP13 (0.51) | PGRMMP13MMP2MMP3MMP14 | |
| SCHEMBL1100587 | 0.74 | MMP13 (0.51) | PGRMMP13MMP2MMP3MMP14 | |
| SCHEMBL1100591 | 0.74 | MMP13 (0.51) | PGRMMP13MMP2MMP3MMP14 | |
| SCHEMBL2129951 | 0.61 | HPGD (0.64) | PGRALDH1A1L3MBTL1PTGS1PTGS2 | |
| SCHEMBL6927009 | 0.59 | PIM1 (0.58) | PGRMAPTNPSR1 | |
| SCHEMBL6752874 | 0.58 | CYP1A2 (0.78) | ALDH1A1L3MBTL1 | |
| SCHEMBL2908147 | 0.58 | CA1 (0.57) | PGRALDH1A1AR | |
| SCHEMBL5801508 | 0.58 | PGR (0.91) | PGRPKMALDH1A1MAPTNPSR1 | |
| SCHEMBL7363201 | 0.57 | PTGS2 (0.56) | PGRALDH1A1PTGS1PTGS2 | |
| SCHEMBL7009516 | 0.56 | SMN1; SMN2 (0.81) | PGRMMP1MMP13MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539740-A1 | SULPHONAMIDE DERIVATIVES AND THEIR USE AS TACE INHIBITORS | AstraZeneca AB (SE) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004024715-A1 | SULPHONAMIDE DERIVATIVES AND THEIR USE AS TACE INHIBITORS | ASTRAZENECA AB (SE) | 2004-03-25 | — | — | WO | disclosed |