Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 12/20 | 0.91 |
| ▸ | AR | P10275 | 1/20 | 0.66 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.66 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.66 |
| ▸ | CES1 | P23141 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | IL1RN | P18510 | 1/20 | 0.59 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.59 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4203669 | 0.92 | PGR (0.96) | PGRARFFAR1FFAR4MAPT | |
| SCHEMBL2133710 | 0.90 | CES1 (0.81) | PGRARCES1MAPTMEN1 | |
| SCHEMBL9231028 | 0.84 | PGR (0.83) | PGRFFAR1FFAR4MAPTMEN1 | |
| SCHEMBL5802392 | 0.84 | PGR (0.68) | PGRFFAR1FFAR4MAPTNPSR1 | |
| SCHEMBL7584032 | 0.83 | CES1 (0.81) | PGRARCES1MEN1KMT2A | |
| SCHEMBL2474197 | 0.80 | CES1 (1.00) | PGRARCES1MAPTMEN1 | |
| SCHEMBL6554630 | 0.80 | CES1 (1.00) | PGRARCES1MAPTMEN1 | |
| SCHEMBL810795 | 0.80 | KMT2A (0.91) | PGRMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL30209715 | 0.80 | CES1 (0.76) | PGRARCES1MEN1KMT2A | |
| SCHEMBL11047587 | 0.79 | MEN1 (0.76) | PGRCES1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651595-A2 | UBIQUITIN LIGASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2006-05-03 | — | — | EP | claimed |
| WO-2005007621-A2 | UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2005-01-27 | — | — | WO | claimed |