Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.41 |
| ▸ | PTAFR | P25105 | 9/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6215209 | 0.88 | ROCK2 (0.40) | ROCK2PTAFRALDH1A1DPP4 | |
| SCHEMBL6212956 | 0.88 | ROCK2 (0.41) | ROCK2PTAFROPRM1OPRD1OPRK1 | |
| SCHEMBL6209605 | 0.87 | DPP4 (0.44) | PTAFRALDH1A1DPP4NAMPT | |
| SCHEMBL5941500 | 0.86 | NAMPT (0.46) | PTAFRALDH1A1DPP4NAMPT | |
| SCHEMBL6209860 | 0.86 | HDAC1 (0.44) | PTAFRDPP4 | |
| SCHEMBL6211981 | 0.85 | ALDH1A1 (0.46) | PTAFRALDH1A1NAMPT | |
| SCHEMBL6212212 | 0.85 | PTAFR (0.42) | PTAFRALDH1A1 | |
| SCHEMBL6211236 | 0.85 | PTAFR (0.40) | PTAFRALDH1A1NAMPT | |
| SCHEMBL6212722 | 0.85 | CHRM4 (0.43) | PTAFRDPP4NAMPT | |
| SCHEMBL6212663 | 0.84 | TAOK1 (0.39) | ROCK2ALDH1A1TAOK1DPP4NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | claimed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | claimed |