SCHEMBL6211981

SCHEMBL6211981

O=C(NCCCCC(=O)N1CCC2C1C(=O)CN2C(=O)Cc1cccnc1)c1ccc(N2CCOCC2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.46
HDAC3 O15379 3/20 0.42
HDAC1 Q13547 2/20 0.42
SMN1; SMN2 Q16637 3/20 0.41
MAPT P10636 1/20 0.41
NAMPT P43490 3/20 0.40
DRD3 P35462 2/20 0.40
HTR1A P08908 1/20 0.40
HTR2A P28223 1/20 0.40
TP53 P04637 1/20 0.39
PTAFR P25105 2/20 0.39
FLT3 P36888 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38
HDAC2 Q92769 1/20 0.38
HDAC10 Q969S8 1/20 0.38
HDAC11 Q96DB2 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
HDAC9 Q9UKV0 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6209605 0.89 DPP4 (0.44) ALDH1A1HDAC3HDAC1SMN1; SMN2MAPT
SCHEMBL5941500 0.87 NAMPT (0.46) ALDH1A1NAMPTPTAFR
SCHEMBL6211528 0.87 ALDH1A1 (0.44) ALDH1A1HDAC3HDAC1SMN1; SMN2MAPT
SCHEMBL6212212 0.87 PTAFR (0.42) ALDH1A1SMN1; SMN2PTAFR
SCHEMBL6211236 0.87 PTAFR (0.40) ALDH1A1HDAC3HDAC1SMN1; SMN2NAMPT
SCHEMBL6212722 0.86 CHRM4 (0.43) NAMPTPTAFR
SCHEMBL6209099 0.85 ROCK2 (0.41) ALDH1A1NAMPTPTAFR
SCHEMBL6259166 0.85 NAMPT (0.41) HDAC3HDAC1NAMPTPTAFR
SCHEMBL6259546 0.85 ALDH1A1 (0.46) ALDH1A1HDAC3HDAC1SMN1; SMN2MAPT
SCHEMBL6209860 0.84 HDAC1 (0.44) HDAC3HDAC1DRD3HTR2APTAFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1546150-A1 BIOLOGICALLY ACTIVE COMPOUNDS Amura Therapeutics Limited (GB) 2005-06-29 EP claimed
WO-2004007501-A1 BIOLOGICALLY ACTIVE COMPOUNDS AMURA THERAPEUTICS LIMITED (GB) 2004-01-22 WO claimed
EP-1546150-A1 BIOLOGICALLY ACTIVE COMPOUNDS Amura Therapeutics Limited (GB) 2005-06-29 EP disclosed
WO-2004007501-A1 BIOLOGICALLY ACTIVE COMPOUNDS AMURA THERAPEUTICS LIMITED (GB) 2004-01-22 WO disclosed