Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP2 | Q6P179 | 5/20 | 0.55 |
| ▸ | IL1RN | P18510 | 3/20 | 0.55 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.55 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.42 |
| ▸ | VEGFA | P15692 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 5/20 | 0.40 |
| ▸ | MMP9 | P14780 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8268695 | 0.81 | MEN1 (0.55) | ERAP2IL1RNERAP1NPC1KDM4E | |
| SCHEMBL621806 | 0.79 | IL1RN (0.45) | ERAP2IL1RNERAP1NPC1KDM4E | |
| SCHEMBL8102285 | 0.77 | ERAP2 (0.54) | ERAP2IL1RNERAP1EGLN1VEGFA | |
| SCHEMBL5179205 | 0.76 | EGLN1 (0.53) | ERAP2IL1RNERAP1EGLN1VEGFA | |
| SCHEMBL10966257 | 0.75 | ERAP2 (0.63) | ERAP2IL1RNERAP1EGLN1VEGFA | |
| SCHEMBL8268679 | 0.75 | ERAP2 (0.66) | ERAP2IL1RNERAP1NPC1RAB9A | |
| SCHEMBL8102037 | 0.75 | ERAP2 (0.59) | ERAP2IL1RNERAP1EGLN1VEGFA | |
| SCHEMBL8102665 | 0.74 | KDM4E (0.50) | ERAP2IL1RNERAP1EGLN1VEGFA | |
| SCHEMBL9513063 | 0.74 | ERAP2 (0.64) | ERAP2IL1RNERAP1EGLN1VEGFA | |
| SCHEMBL9511617 | 0.74 | ERAP2 (0.64) | ERAP2IL1RNERAP1EGLN1VEGFA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318945-B2 | Metalloprotein inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120041032-A1 | METALLOPROTEIN INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO (US) | 2012-02-16 | — | — | US | disclosed |
| US-8008510-B2 | Metalloprotein inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-08-30 | — | — | US | disclosed |
| US-7786316-B2 | Metalloprotein inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-08-31 | — | — | US | disclosed |
| US-20100173952-A1 | METALLOPROTEIN INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA OFFICE OF TECHNOLOGY TRANSFER (US) | 2010-07-08 | — | — | US | disclosed |
| US-7705164-B2 | Metalloprotein inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-04-27 | — | — | US | disclosed |
| US-20090286987-A1 | METALLOPROTEIN INHIBITORS | REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO UCSD TECHNOLOGY TRANSFER OFFICE (US) | 2009-11-19 | — | — | US | disclosed |
| US-7579486-B2 | Metalloprotein inhibitors | REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO (US) | 2009-08-25 | — | — | US | disclosed |
| US-20080161362-A1 | Metalloprotein Inhibitors | REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO UCSD TECHNOLOGY TRANSFER OFFICE (US) | 2008-07-03 | — | — | US | disclosed |
| US-20070117848-A1 | METALLOPROTEIN INHIBITORS | REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO | 2007-05-24 | — | — | US | disclosed |
| EP-1755586-A2 | HYDROXYPYRIDINONE, HYDROXYPYRIDINETHIONE, PYRONE, AND THIOPYRONE METALLOPROTEIN INHIBITORS | The Regents of the University of California (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2006028523-A2 | HYDROXYPYRIDINONE, HYDROXYPYRIDINETHIONE, PYRONE, AND THIOPYRONE METALLOPROTEIN INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO USDC Technology Transfer Office (US) | 2006-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286987-A1 | METALLOPROTEIN INHIBITORS | SOD1, ZFX, SOD3 | ERAP2 1068/4885IL1RN 948/4885ERAP1 314/4885 |
| US-20080161362-A1 | Metalloprotein Inhibitors | SOD1, ZFX, SOD3 | ERAP2 1068/4885IL1RN 948/4885ERAP1 314/4885 |
| US-20100173952-A1 | METALLOPROTEIN INHIBITORS | SOD1, ZFX, SOD3 | ERAP2 1068/4885IL1RN 948/4885ERAP1 314/4885 |
| US-20070117848-A1 | METALLOPROTEIN INHIBITORS | SOD1, ZFX, SOD3 | ERAP2 1068/4885IL1RN 948/4885ERAP1 314/4885 |
| US-20120041032-A1 | METALLOPROTEIN INHIBITORS | SOD1, ZFX, SOD3 | ERAP2 1068/4885IL1RN 948/4885ERAP1 314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.