Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1RN | P18510 | 2/20 | 0.45 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.45 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8106275 | 0.85 | IL1RN (0.49) | IL1RNERAP2ERAP1MAPK14KDM4E | |
| SCHEMBL8100824 | 0.83 | MAPK14 (0.49) | IL1RNERAP2ERAP1MAPK14MAPT | |
| SCHEMBL8102567 | 0.83 | BRD4 (0.54) | IL1RNERAP2ERAP1MAPK14KDM4E | |
| SCHEMBL8106183 | 0.81 | KDM4E (0.51) | IL1RNERAP2ERAP1KDM4EMAPT | |
| SCHEMBL20382946 | 0.81 | MAPK14 (0.49) | IL1RNERAP2ERAP1MAPK14MAPT | |
| SCHEMBL621015 | 0.79 | ERAP2 (0.55) | IL1RNERAP2ERAP1KDM4ENPC1 | |
| SCHEMBL8102831 | 0.79 | KDM4E (0.49) | IL1RNERAP2ERAP1KDM4EMAPT | |
| SCHEMBL622182 | 0.78 | ALDH1A1 (0.50) | KDM4EMAPTNPC1HTTBRD4 | |
| SCHEMBL9512037 | 0.76 | KDM4E (0.44) | IL1RNERAP2ERAP1KDM4EMAPT | |
| SCHEMBL271730 | 0.76 | MAPK14 (0.68) | MAPK14KDM4EMAPTNPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318945-B2 | Metalloprotein inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120041032-A1 | METALLOPROTEIN INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO (US) | 2012-02-16 | — | — | US | disclosed |
| US-8008510-B2 | Metalloprotein inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-08-30 | — | — | US | disclosed |
| US-7786316-B2 | Metalloprotein inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-08-31 | — | — | US | disclosed |
| US-20100173952-A1 | METALLOPROTEIN INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA OFFICE OF TECHNOLOGY TRANSFER (US) | 2010-07-08 | — | — | US | disclosed |
| US-7705164-B2 | Metalloprotein inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-04-27 | — | — | US | disclosed |
| US-20090286987-A1 | METALLOPROTEIN INHIBITORS | REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO UCSD TECHNOLOGY TRANSFER OFFICE (US) | 2009-11-19 | — | — | US | disclosed |
| US-7579486-B2 | Metalloprotein inhibitors | REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO (US) | 2009-08-25 | — | — | US | disclosed |
| US-20080161362-A1 | Metalloprotein Inhibitors | REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO UCSD TECHNOLOGY TRANSFER OFFICE (US) | 2008-07-03 | — | — | US | disclosed |
| US-20070117848-A1 | METALLOPROTEIN INHIBITORS | REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO | 2007-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286987-A1 | METALLOPROTEIN INHIBITORS | SOD1, ZFX, SOD3 | IL1RN 948/4885ERAP2 1068/4885ERAP1 314/4885 |
| US-20080161362-A1 | Metalloprotein Inhibitors | SOD1, ZFX, SOD3 | IL1RN 948/4885ERAP2 1068/4885ERAP1 314/4885 |
| US-20100173952-A1 | METALLOPROTEIN INHIBITORS | SOD1, ZFX, SOD3 | IL1RN 948/4885ERAP2 1068/4885ERAP1 314/4885 |
| US-20070117848-A1 | METALLOPROTEIN INHIBITORS | SOD1, ZFX, SOD3 | IL1RN 948/4885ERAP2 1068/4885ERAP1 314/4885 |
| US-20120041032-A1 | METALLOPROTEIN INHIBITORS | SOD1, ZFX, SOD3 | IL1RN 948/4885ERAP2 1068/4885ERAP1 314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.