Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4324591 | 0.82 | ALDH1A1 (0.40) | TDP1ALDH1A1HSD17B10LMNARAPGEF4 | |
| SCHEMBL11139384 | 0.80 | RAPGEF4 (0.39) | TDP1ALDH1A1HSD17B10LMNARAPGEF4 | |
| SCHEMBL6180421 | 0.78 | SOS1 (0.42) | TDP1ALDH1A1HSD17B10LMNA | |
| SCHEMBL16908538 | 0.78 | ALDH1A1 (0.37) | TDP1ALDH1A1HSD17B10LMNA | |
| SCHEMBL11524720 | 0.78 | CA1 (0.46) | TDP1ALDH1A1HSD17B10LMNA | |
| SCHEMBL6143116 | 0.75 | LMNA (0.42) | TDP1ALDH1A1HSD17B10LMNARAPGEF4 | |
| SCHEMBL11046134 | 0.75 | ALDH1A1 (0.34) | TDP1ALDH1A1HSD17B10LMNA | |
| SCHEMBL5212407 | 0.75 | ALDH1A1 (0.38) | TDP1ALDH1A1HSD17B10LMNARAPGEF4 | |
| SCHEMBL305764 | 0.75 | PTGS2 (0.46) | TDP1ALDH1A1HSD17B10LMNA | |
| SCHEMBL218559 | 0.74 | ALDH1A1 (0.53) | TDP1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507763-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | Bayer HealthCare AG (DE) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003097607-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2003-11-27 | — | — | WO | disclosed |