Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.39 |
| ▸ | PTAFR | P25105 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.37 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.37 |
| ▸ | GCGR | P47871 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6211755 | 0.92 | DPP4 (0.45) | NAMPTPPARDPTAFRSMYD3SLC6A5 | |
| SCHEMBL6210722 | 0.90 | CHRM4 (0.42) | NAMPTCHRM4PTAFRDPP4 | |
| SCHEMBL6258369 | 0.90 | LMNA (0.44) | NAMPTCHRM2CHRM1PPARDCHRM4 | |
| SCHEMBL6210118 | 0.89 | DPP4 (0.44) | NAMPTPTAFRHDAC3HDAC1SMYD3 | |
| SCHEMBL6275935 | 0.88 | NAMPT (0.41) | NAMPTCHRM2CHRM1PPARDCHRM4 | |
| SCHEMBL6259166 | 0.87 | NAMPT (0.41) | NAMPTCHRM2CHRM1CHRM4CXCR3 | |
| SCHEMBL6211528 | 0.85 | ALDH1A1 (0.44) | NAMPTPTAFRHDAC3HDAC1SMYD3 | |
| SCHEMBL6210861 | 0.85 | HDAC1 (0.41) | NAMPTPTAFRHDAC3HDAC1SMYD3 | |
| SCHEMBL6210587 | 0.84 | HDAC1 (0.42) | CHRM4PTAFRHDAC3HDAC1DPP4 | |
| SCHEMBL6215209 | 0.84 | ROCK2 (0.40) | PTAFRSMYD3DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | claimed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | claimed |
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |