Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | PTAFR | P25105 | 7/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6210489 | 0.88 | CHRM4 (0.39) | HDAC1HDAC3CHRM4DPP4PREP | |
| SCHEMBL6211755 | 0.88 | DPP4 (0.45) | PTAFRDPP4 | |
| SCHEMBL6210118 | 0.88 | DPP4 (0.44) | HDAC1HDAC3PTAFRDPP4 | |
| SCHEMBL6209860 | 0.88 | HDAC1 (0.44) | HDAC1HDAC3CHRM4PTAFRDPP4 | |
| SCHEMBL6215209 | 0.86 | ROCK2 (0.40) | PTAFRDPP4 | |
| SCHEMBL6210861 | 0.86 | HDAC1 (0.41) | HDAC1HDAC3PTAFRHTR2AHDAC2 | |
| SCHEMBL6210722 | 0.85 | CHRM4 (0.42) | CHRM4PTAFRDPP4 | |
| SCHEMBL6211528 | 0.85 | ALDH1A1 (0.44) | HDAC1HDAC3PTAFRHTR2A | |
| SCHEMBL6211580 | 0.84 | NAMPT (0.43) | HDAC1HDAC3CHRM4PTAFRDPP4 | |
| SCHEMBL4042901 | 0.82 | CTSK (0.47) | HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | claimed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | claimed |