Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAPDH | P04406 | 1/20 | 0.38 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.38 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6213227 | 0.89 | MEN1 (0.39) | MEN1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6212304 | 0.83 | HSPA1A (0.53) | MEN1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6214662 | 0.76 | POLB (0.34) | MEN1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4712096 | 0.76 | MEN1 (0.36) | MEN1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6213144 | 0.75 | HSPA1A (0.51) | MEN1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4713720 | 0.74 | GAPDH (0.35) | MEN1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6641218 | 0.72 | GAPDH (0.42) | MEN1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6214848 | 0.71 | GAPDH (0.68) | MEN1KMT2AGAPDHHSPA1AHSPA8 | |
| SCHEMBL4714145 | 0.71 | GAPDH (0.33) | MEN1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4715612 | 0.71 | GAPDH (0.33) | MEN1CYP1A2CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254118-B1 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | GRUENENTHAL GMBH (DE) | 2005-11-09 | — | — | EP | claimed |
| EP-1254118-B1 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | GRUENENTHAL GMBH (DE) | 2005-11-09 | — | — | EP | disclosed |