Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA1A | P0DMV8 | 2/20 | 0.53 |
| ▸ | GAPDH | P04406 | 1/20 | 0.53 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6213144 | 0.89 | HSPA1A (0.51) | HSPA1AGAPDHHSPA8MEN1KMT2A | |
| SCHEMBL6212040 | 0.83 | MEN1 (0.40) | HSPA1AGAPDHHSPA8MEN1KMT2A | |
| SCHEMBL6213227 | 0.75 | MEN1 (0.39) | HSPA1AGAPDHHSPA8MEN1KMT2A | |
| SCHEMBL4712095 | 0.74 | HSPA1A (0.47) | HSPA1AGAPDHHSPA8MEN1KMT2A | |
| SCHEMBL6211966 | 0.74 | MEN1 (0.40) | MEN1KMT2APOLBL3MBTL1 | |
| SCHEMBL4713073 | 0.72 | GAPDH (0.47) | HSPA1AGAPDHHSPA8MEN1KMT2A | |
| SCHEMBL6641216 | 0.70 | GAPDH (0.60) | HSPA1AGAPDHHSPA8MEN1KMT2A | |
| SCHEMBL6087749 | 0.69 | HSPA1A (1.00) | HSPA1AGAPDHHSPA8MEN1KMT2A | |
| SCHEMBL4712217 | 0.69 | GAPDH (0.44) | HSPA1AGAPDHHSPA8MEN1KMT2A | |
| SCHEMBL4712093 | 0.69 | GAPDH (0.44) | HSPA1AGAPDHHSPA8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254118-B1 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | GRUENENTHAL GMBH (DE) | 2005-11-09 | — | — | EP | claimed |
| US-20040224969-A1 | Salts of substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid compounds | GRUENENTHAL GMBH (DE) | 2004-11-11 | — | — | US | claimed |
| EP-1254118-B1 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | GRUENENTHAL GMBH (DE) | 2005-11-09 | — | — | EP | disclosed |
| US-20040224969-A1 | Salts of substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid compounds | GRUENENTHAL GMBH (DE) | 2004-11-11 | — | — | US | disclosed |
| US-6699877-B2 | TREATING PAIN, MIGRAINE, AND VARIOUS OTHER DISEASES | GRUENENTHAL GMBH (DE) | 2004-03-02 | — | — | US | disclosed |
| US-20030087926-A1 | Substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid derivatives | GRUENENTHAL GMBH | 2003-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087926-A1 | Substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid derivatives | SDHA, CACNA1A, GRIN2C | HSPA1A 3371/4885GAPDH 1284/4885HSPA8 4627/4885 |
| US-20040224969-A1 | Salts of substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acid compounds | OPRK1, SDHA, GRIN2C | HSPA1A 2266/4885GAPDH 749/4885HSPA8 3878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.