Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 9/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 9/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 9/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 9/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 9/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 9/20 | 0.42 |
| ▸ | REN | P00797 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6214947 | 0.78 | CTSD (0.37) | KMT2ACTSS | |
| SCHEMBL4762162 | 0.77 | MAPK1 (0.41) | MAPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4763254 | 0.75 | CTSD (0.38) | CTSS | |
| SCHEMBL4763258 | 0.75 | CTSD (0.38) | CTSS | |
| SCHEMBL6611358 | 0.74 | MAPK1 (0.36) | MAPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4320742 | 0.72 | CTSK (0.46) | MAPK1RENKMT2AALDH1A1CTSS | |
| SCHEMBL4320739 | 0.72 | CTSK (0.46) | MAPK1RENKMT2AALDH1A1CTSS | |
| SCHEMBL3822986 | 0.71 | MAPK1 (0.50) | MAPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1957769 | 0.71 | HSD11B1 (0.45) | — | |
| SCHEMBL17965902 | 0.71 | HSD11B1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307203-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-1307203-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2001070232-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-27 | — | — | WO | disclosed |