Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.72 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.72 |
| ▸ | MEN1 | O00255 | 7/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.72 |
| ▸ | TP53 | P04637 | 6/20 | 0.72 |
| ▸ | HTT | P42858 | 5/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.72 |
| ▸ | USP2 | O75604 | 3/20 | 0.72 |
| ▸ | COMT | P21964 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | MPI | P34949 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL113119 | 0.86 | KDM4E (0.72) | KDM4EHSP90AA1MEN1KMT2ATP53 | |
| SCHEMBL31083553 | 0.86 | KDM4E (0.57) | KDM4EHSP90AA1MEN1KMT2ATP53 | |
| Broxyquinoline SCHEMBL30485535 | 0.84 | KDM4E (1.00) | KDM4EHSP90AA1MEN1KMT2ATP53 | |
| SCHEMBL16207365 | 0.84 | KDM4E (0.62) | KDM4EHSP90AA1MEN1KMT2ATP53 | |
| Broxyquinoline SCHEMBL29607319 | 0.84 | KDM4E (1.00) | KDM4EHSP90AA1MEN1KMT2ATP53 | |
| Broxyquinoline SCHEMBL115293 | 0.84 | KDM4E (1.00) | KDM4EHSP90AA1MEN1KMT2ATP53 | |
| Broxyquinoline SCHEMBL261708 | 0.82 | KDM4E (0.96) | KDM4EHSP90AA1MEN1KMT2ATP53 | |
| Broxyquinoline SCHEMBL22734870 | 0.82 | KDM4E (0.96) | KDM4EHSP90AA1MEN1KMT2ATP53 | |
| Broxyquinoline SCHEMBL31157810 | 0.82 | KDM4E (0.96) | KDM4EHSP90AA1MEN1KMT2ATP53 | |
| Broxyquinoline SCHEMBL28536097 | 0.82 | KDM4E (0.96) | KDM4EHSP90AA1MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110790772-B | Hydroxyquinoline-based metal organic micromolecule complex material grafted with perylene diimide and aromatic group and preparation method and application thereof | 华南理工大学 | 2022-10-25 | — | — | CN | disclosed |
| US-11434203-B2 | 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents | THE GENERAL HOSPITAL CORPORATION (US) | 2022-09-06 | — | — | US | disclosed |
| CN-110790760-B | Fluorohydroxyquinolyl metal organic small molecular complex with aromatic group bridging naphthalimide and preparation method and application thereof | 华南理工大学 | 2022-07-26 | — | — | CN | disclosed |
| US-20210024468-A1 | 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS | THE GENERAL HOSPITAL CORPORATION | 2021-01-28 | — | — | US | disclosed |
| US-20210024468-A1 | 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS | THE GENERAL HOSPITAL CORPORATION | 2021-01-28 | — | — | US | disclosed |
| US-10781178-B2 | 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-22 | — | — | US | disclosed |
| US-10781178-B2 | 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-22 | — | — | US | disclosed |
| CN-110790772-A | Hydroxyquinoline-based metal organic micromolecule complex material grafted with perylene diimide and aromatic group and preparation method and application thereof | 华南理工大学 | 2020-02-14 | — | — | CN | disclosed |
| CN-110790760-A | Fluorohydroxyquinolyl metal organic small molecular complex with aromatic group bridging naphthalimide and preparation method and application thereof | 华南理工大学 | 2020-02-14 | — | — | CN | disclosed |
| US-20180327362-A1 | 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS | THE GENERAL HOSPITAL CORPORATION | 2018-11-15 | — | — | US | disclosed |
| US-9034303-B2 | Neuroprotective and neuro-restorative iron chelators and monoamine oxidase inhibitors and uses thereof | ZURAWSKI JR VINCENT R (US) | 2015-05-19 | — | — | US | disclosed |
| US-9034303-B2 | Neuroprotective and neuro-restorative iron chelators and monoamine oxidase inhibitors and uses thereof | ZURAWSKI JR VINCENT R (US) | 2015-05-19 | — | — | US | disclosed |
| US-20140186280-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | VARINEL INC (US) | 2014-07-03 | — | — | US | disclosed |
| US-20140186280-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | VARINEL INC (US) | 2014-07-03 | — | — | US | disclosed |
| US-20140186280-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | VARINEL INC (US) | 2014-07-03 | — | — | US | disclosed |
| US-20130330284-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | VARINEL INC (US) | 2013-12-12 | — | — | US | disclosed |
| CN-103298790-A | Iron chelator and monoamine oxidase inhibitor with neuroprotective and neurorestorative effects and uses thereof | VARINEL INC | 2013-09-11 | — | — | CN | disclosed |
| EP-2603492-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | Varinel Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012020389-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | VARINEL INC (US) | 2012-02-16 | — | — | WO | disclosed |
| WO-2012020389-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | VARINEL INC (US) | 2012-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11434203-B2 | 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents | KLK3, COQ8A, PARK7 | KDM4E 2935/4885HSP90AA1 2113/4885MEN1 72/4885 |
| US-20140186280-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | MAOA, MAOB, FECH | KDM4E 183/4885HSP90AA1 2370/4885MEN1 3904/4885 |
| US-20210024468-A1 | 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS | KLK3, COQ8A, PARK7 | KDM4E 2935/4885HSP90AA1 2113/4885MEN1 72/4885 |
| US-20180327362-A1 | 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS | KLK3, COQ8A, PARK7 | KDM4E 2935/4885HSP90AA1 2113/4885MEN1 72/4885 |
| US-10781178-B2 | 8-hydroxyquinoline derivatives as diagnostic and therapeutic agents | KLK3, COQ8A, PARK7 | KDM4E 2935/4885HSP90AA1 2113/4885MEN1 72/4885 |
| US-20130330284-A1 | NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF | MAOA, MAOB, FECH | KDM4E 183/4885HSP90AA1 2370/4885MEN1 3904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.