Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | CCNC | P24863 | 2/20 | 0.39 |
| ▸ | CDK8 | P49336 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22784143 | 0.73 | CCNC (0.51) | L3MBTL1ALDH1A1TAAR1SMN1; SMN2KDM4E | |
| SCHEMBL27851103 | 0.68 | KDM4E (0.40) | ALDH1A1TAAR1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL6965186 | 0.68 | KDM4E (0.47) | L3MBTL1ALDH1A1TAAR1SMN1; SMN2KDM4E | |
| SCHEMBL3288225 | 0.68 | NPC1 (0.63) | L3MBTL1ALDH1A1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL1780240 | 0.66 | MCL1 (0.46) | L3MBTL1ALDH1A1KDM4ETSHRHPGD | |
| SCHEMBL22784145 | 0.65 | ALDH1A1 (0.57) | L3MBTL1ALDH1A1TAAR1SMN1; SMN2KDM4E | |
| SCHEMBL2243709 | 0.64 | NPC1 (0.52) | L3MBTL1ALDH1A1TAAR1SMN1; SMN2KDM4E | |
| SCHEMBL8557281 | 0.64 | L3MBTL1 (0.53) | L3MBTL1ALDH1A1TAAR1SMN1; SMN2KDM4E | |
| SCHEMBL17554284 | 0.64 | ELANE (0.51) | L3MBTL1TAAR1SMN1; SMN2KDM4EPKM | |
| SCHEMBL20494780 | 0.64 | HDAC3 (0.55) | L3MBTL1ALDH1A1TAAR1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1450811-A4 | 2-ARYL PYRROLOPYRIMIDINES FOR A1 AND A3 RECEPTORS | OSI PHARM INC (US) | 2005-11-16 | — | — | EP | disclosed |
| EP-1347980-A4 | COMPOUNDS SPECIFIC TO ADENOSINE-A1,-A2A, AND- A3-RECEPTOR AND USES THEREOF | OSI PHARM INC (US) | 2005-02-09 | — | — | EP | disclosed |
| EP-1450811-A2 | 2-ARYL PYRROLOPYRIMIDINES FOR A1 AND A3 RECEPTORS | Osi Pharmaceuticals, Inc. (US) | 2004-09-01 | — | — | EP | disclosed |
| EP-1347980-A1 | COMPOUNDS SPECIFIC TO ADENOSINE-A1,-A2A, AND- A3-RECEPTOR AND USES THEREOF | OSI Pharmaceuticals, Inc. (US) | 2003-10-01 | — | — | EP | disclosed |
| WO-2003048120-A2 | 2-ARYL PYRROLOGPYRIMIDINES FOR A1 AND A3 RECEPTORS | OSI PHARMACEUTICALS, INC. (US) | 2003-06-12 | — | — | WO | disclosed |
| WO-2002057267-A1 | COMPOUNDS SPECIFIC TO ADENOSINE A1, A2A, AND A3 RECEPTOR AND USES THEREOF | OSI PHARMACEUTICALS, INC. (US) | 2002-07-25 | — | — | WO | disclosed |