Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | CFTR | P13569 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 2/20 | 0.48 |
| ▸ | CES1 | P23141 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30432593 | 1.00 | CA12 (0.53) | CA12CA1CA2CA7CA9 | |
| SCHEMBL26247276 | 0.89 | KMT2A (0.59) | CA12CA1CA2CA7CA9 | |
| SCHEMBL852026 | 0.89 | ALB (0.52) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1586012 | 0.89 | KMT2A (0.47) | CA12CA1CA2CA7CA9 | |
| SCHEMBL31159165 | 0.89 | KMT2A (0.59) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1070351 | 0.88 | CA12 (0.61) | CA12CA1CA2CA7CA9 | |
| SCHEMBL13735592 | 0.87 | ALDH1A1 (0.49) | CA12CA1CA2CA7CA9 | |
| SCHEMBL853194 | 0.87 | ALDH1A1 (0.53) | CA12CA1CA2CA7CA9 | |
| SCHEMBL13733976 | 0.87 | CA12 (0.48) | CA12CA1CA2CA7CA9 | |
| SCHEMBL29232789 | 0.86 | KMT2A (0.49) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170255100-A1 | DRY FILM STRUCTURE | FUJIFILM ELECTRONIC MATERIALS U.S.A., INC. | 2017-09-07 | — | — | US | disclosed |
| CN-101874019-B | Process for preparing isoindole derivatives and process for preparing intermediates thereof | HOFFMANN LA ROCHE | 2013-06-12 | — | — | CN | disclosed |
| US-20130060038-A1 | PREPARATION OF DIHYDROPYRROL DERIVATIVES AS INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 2013-03-07 | — | — | US | disclosed |
| US-20130060038-A1 | PREPARATION OF DIHYDROPYRROL DERIVATIVES AS INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 2013-03-07 | — | — | US | disclosed |
| US-20130060038-A1 | PREPARATION OF DIHYDROPYRROL DERIVATIVES AS INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 2013-03-07 | — | — | US | disclosed |
| US-20120041205-A1 | PREPARATION OF DIHYDROPYRROL DERIVATIVES AS INTERMEDIATES | PFLEGER CHRISTOPHE (FR) | 2012-02-16 | — | — | US | disclosed |
| US-20120041205-A1 | PREPARATION OF DIHYDROPYRROL DERIVATIVES AS INTERMEDIATES | PFLEGER CHRISTOPHE (FR) | 2012-02-16 | — | — | US | disclosed |
| US-20120041205-A1 | PREPARATION OF DIHYDROPYRROL DERIVATIVES AS INTERMEDIATES | PFLEGER CHRISTOPHE (FR) | 2012-02-16 | — | — | US | disclosed |
| EP-2225202-B1 | Preparation of dihydropyrrol derivatives as intermediates | HOFFMANN LA ROCHE (CH) | 2011-12-28 | — | — | EP | disclosed |
| CN-101874019-A | Process for preparing isoindole derivatives and process for preparing intermediates thereof | HOFFMANN LA ROCHE | 2010-10-27 | — | — | CN | disclosed |
| EP-2225202-A2 | PROCESS FOR THE PREPARATION OF ISOINDOLE DERIVATIVES AS WELL AS A PROCESS FOR THE PREPARATION OF THEIR INTERMEDIATES | F. Hoffmann-La Roche AG (CH) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009068463-A2 | PROCESS FOR THE PREPARATION OF ISOINDOLE DERIVATIVES AS WELL AS A PROCESS FOR THE PREPARATION OF THEIR INTERMEDIATES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009068463-A2 | PROCESS FOR THE PREPARATION OF ISOINDOLE DERIVATIVES AS WELL AS A PROCESS FOR THE PREPARATION OF THEIR INTERMEDIATES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-04 | — | — | WO | disclosed |
| US-20090143589-A1 | Preparation of dihydropyrrol derivatives as intermediates | ROCHE PALO ALTO LLC | 2009-06-04 | — | — | US | disclosed |
| US-20090143589-A1 | Preparation of dihydropyrrol derivatives as intermediates | ROCHE PALO ALTO LLC | 2009-06-04 | — | — | US | disclosed |
| US-20090143589-A1 | Preparation of dihydropyrrol derivatives as intermediates | ROCHE PALO ALTO LLC | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143589-A1 | Preparation of dihydropyrrol derivatives as intermediates | DHPS, QDPR, SDHA | CA12 2775/4885CA1 3372/4885CA2 1939/4885 |
| US-20120041205-A1 | PREPARATION OF DIHYDROPYRROL DERIVATIVES AS INTERMEDIATES | DHPS, QDPR, SDHA | CA12 2775/4885CA1 3372/4885CA2 1939/4885 |
| US-20130060038-A1 | PREPARATION OF DIHYDROPYRROL DERIVATIVES AS INTERMEDIATES | DHPS, QDPR, SDHA | CA12 2775/4885CA1 3372/4885CA2 1939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.