Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.55 |
| ▸ | PARP1 | P09874 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7707225 | 0.84 | KIF11 (0.55) | KIF11PARP1RAB9ADYRK1AALDH1A1 | |
| SCHEMBL5881993 | 0.78 | PTGS2 (0.47) | KIF11PARP1RAB9ADYRK1AALDH1A1 | |
| SCHEMBL24100470 | 0.78 | GPR84 (0.68) | KIF11PARP1RAB9AKMT2AMEN1 | |
| SCHEMBL29708168 | 0.77 | KIF11 (0.84) | KIF11PARP1RAB9ADYRK1AALDH1A1 | |
| SCHEMBL4725998 | 0.77 | KIF11 (0.84) | KIF11PARP1RAB9ADYRK1AALDH1A1 | |
| SCHEMBL7419884 | 0.76 | KIF11 (0.58) | KIF11PARP1RAB9ADYRK1AALDH1A1 | |
| SCHEMBL7422570 | 0.76 | KIF11 (0.55) | KIF11PARP1RAB9ADYRK1AALDH1A1 | |
| SCHEMBL14001411 | 0.74 | KIF11 (0.52) | KIF11PARP1RAB9AALDH1A1KDM4E | |
| SCHEMBL7541380 | 0.74 | KIF11 (0.56) | KIF11PARP1RAB9ADYRK1AALDH1A1 | |
| SCHEMBL6009589 | 0.74 | KIF11 (0.72) | KIF11PARP1RAB9ADYRK1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560584-A4 | FAB I INHIBITORS | AFFINIUM PHARM INC (CA) | 2005-10-12 | — | — | EP | disclosed |
| EP-1560584-A2 | FAB I INHIBITORS | Affinium Pharmaceuticals, Inc. (CA) | 2005-08-10 | — | — | EP | disclosed |
| WO-2003088897-A2 | FAB I INHIBITORS | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2003-10-30 | — | — | WO | disclosed |