Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.55 |
| ▸ | PARP1 | P09874 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6217545 | 0.84 | KIF11 (0.55) | KIF11PARP1RAB9ADYRK1AKDM4E | |
| SCHEMBL7419884 | 0.79 | KIF11 (0.58) | KIF11PARP1RAB9ADYRK1AKDM4E | |
| SCHEMBL29708168 | 0.77 | KIF11 (0.84) | KIF11PARP1RAB9ADYRK1AKDM4E | |
| SCHEMBL4725998 | 0.77 | KIF11 (0.84) | KIF11PARP1RAB9ADYRK1AKDM4E | |
| SCHEMBL5881993 | 0.76 | PTGS2 (0.47) | KIF11PARP1RAB9ADYRK1AKDM4E | |
| SCHEMBL7422570 | 0.76 | KIF11 (0.55) | KIF11PARP1RAB9ADYRK1AKDM4E | |
| SCHEMBL24100470 | 0.75 | GPR84 (0.68) | KIF11PARP1RAB9AKMT2AMEN1 | |
| SCHEMBL31571572 | 0.74 | NPC1 (0.71) | KIF11PARP1RAB9ANPC1 | |
| SCHEMBL27142464 | 0.74 | NPC1 (0.71) | KIF11PARP1RAB9ANPC1 | |
| SCHEMBL7541380 | 0.74 | KIF11 (0.56) | KIF11PARP1RAB9ADYRK1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |