Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6217582 | 0.73 | GABRA1 (0.40) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL5261894 | 0.72 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL6221519 | 0.70 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL5771903 | 0.70 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL7224848 | 0.69 | GABRG2 (0.43) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL6217979 | 0.69 | GABRA1 (0.34) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL6219147 | 0.69 | GABRA1 (0.43) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL7226778 | 0.67 | GABRA1 (0.33) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL5772206 | 0.67 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL6217150 | 0.66 | SMN1; SMN2 (0.33) | GABRA1GABRG2GABRB3GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1381606-B1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2005-07-20 | — | — | EP | disclosed |