Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2038692 | 0.74 | KDM4E (0.50) | KDM4ETDP1TP53 | |
| SCHEMBL8992127 | 0.64 | GOT1 (0.31) | — | |
| SCHEMBL171853 | 0.62 | HDAC8 (0.47) | KDM4ETDP1TP53 | |
| SCHEMBL30800591 | 0.59 | HDAC8 (0.44) | KDM4ETDP1TP53 | |
| SCHEMBL17144230 | 0.59 | HDAC8 (0.44) | KDM4ETDP1TP53 | |
| SCHEMBL4270187 | 0.59 | HDAC8 (0.44) | KDM4ETDP1TP53 | |
| SCHEMBL29810143 | 0.59 | HDAC8 (0.44) | KDM4ETDP1TP53 | |
| Hydrochloric Acid SCHEMBL6534749 | 0.59 | HDAC8 (0.44) | KDM4ETDP1TP53 | |
| Iodide SCHEMBL28731796 | 0.59 | HDAC8 (0.44) | KDM4ETDP1TP53 | |
| SCHEMBL28383937 | 0.59 | HDAC8 (0.44) | KDM4ETDP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458717-B1 | AROYL PYRIDINONES | BAYER HEALTHCARE AG (DE) | 2005-09-07 | — | — | EP | disclosed |
| US-20050070555-A1 | Aroyl pyridinones | BAYER HEALTHCARE AG | 2005-03-31 | — | — | US | disclosed |
| EP-1458717-A1 | AROYL PYRIDINONES | Bayer HealthCare AG (DE) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003053967-A1 | AROYL PYRIDINONES | BAYER HEALTHCARE AG (DE) | 2003-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070555-A1 | Aroyl pyridinones | PNPO, NDUFV2, NDUFS6 | KDM4E 1594/4885TDP1 3177/4885TP53 4207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.