Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.83 |
| ▸ | GAA | P10253 | 3/20 | 0.83 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.83 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.83 |
| ▸ | HPGD | P15428 | 6/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | NPC1 | O15118 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 2/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.65 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | IKBKB | O14920 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | CASP7 | P55210 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1322128 | 0.91 | MEN1 (0.73) | MAPTKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL6216362 | 0.91 | MAPT (0.70) | MAPTKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL6218571 | 0.89 | MAPT (0.73) | MAPTKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL6214310 | 0.89 | KDM4E (0.67) | MAPTKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL6215605 | 0.89 | ALDH1A1 (0.73) | MAPTKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL6217262 | 0.83 | MAPT (0.86) | MAPTKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL4194506 | 0.82 | LIMK1 (0.82) | MAPTKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL7496360 | 0.82 | MAPT (0.84) | MAPTKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL7505903 | 0.82 | MAPT (0.62) | MAPTKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL21973659 | 0.81 | HPGD (0.62) | MAPTKDM4EALDH1A1GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200140453-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-05-07 | — | — | US | disclosed |
| US-10301320-B2 | Compositions and methods of modulating 15-PGDH activity | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2019-05-28 | — | — | US | disclosed |
| US-9790233-B2 | Compositions and methods of modulating 15-PGDH activity | CASE WESTERN RESERVE UNIVERSITY (US) | 2017-10-17 | — | — | US | disclosed |
| US-9790233-B2 | Compositions and methods of modulating 15-PGDH activity | CASE WESTERN RESERVE UNIVERSITY (US) | 2017-10-17 | — | — | US | disclosed |
| US-20170165241-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2017-06-15 | — | — | US | disclosed |
| US-20170165241-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2017-06-15 | — | — | US | disclosed |
| US-20150072998-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2015-03-12 | — | — | US | disclosed |
| US-20150072998-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2015-03-12 | — | — | US | disclosed |
| EP-1171443-B1 | BICYCLIC HETEROAROMATIC COMPOUNDS USEFUL AS LH AGONISTS | AKZO NOBEL NV (NL) | 2005-07-13 | — | — | EP | disclosed |
| US-6841553-B2 | Bicyclic heteroaromatic compounds useful as LH agonists | AKZO NOBEL N.V. (NL) | 2005-01-11 | — | — | US | disclosed |
| US-20030212081-A1 | Bicyclic heteroaromatic compounds useful as LH agonists | MERCK SHARP & DOHME B.V. (NL) | 2003-11-13 | — | — | US | disclosed |
| US-6569863-B1 | Luteinizing hormone (LH) agonists for controlling fertility | AKZO NOBEL NV (NL) | 2003-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212081-A1 | Bicyclic heteroaromatic compounds useful as LH agonists | LHCGR, GNRHR, FSHR | MAPT 4619/4885KDM4E 2123/4885ALDH1A1 757/4885 |
| US-20170165241-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | PTGS1, HPGD, PTGIS | MAPT 4311/4885KDM4E 3434/4885ALDH1A1 415/4885 |
| US-20200140453-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | PTGS1, HPGD, PTGIS | MAPT 4311/4885KDM4E 3434/4885ALDH1A1 415/4885 |
| US-20150072998-A1 | COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY | PTGS1, HPGD, PTGIS | MAPT 4311/4885KDM4E 3434/4885ALDH1A1 415/4885 |
| US-10301320-B2 | Compositions and methods of modulating 15-PGDH activity | PTGS1, HPGD, PTGIS | MAPT 4311/4885KDM4E 3434/4885ALDH1A1 415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.