Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1223274 | 0.85 | APP (0.44) | KDM4EMAPTNPC1ALDH1A1GAA | |
| SCHEMBL9620838 | 0.84 | RARA (0.47) | KDM4EMEN1MAPTKMT2ANPC1 | |
| SCHEMBL8010166 | 0.84 | ALDH1A1 (0.51) | TRPV1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL9621138 | 0.83 | SMN1; SMN2 (0.52) | BACE1KDM4EMAPTKMT2ANPC1 | |
| SCHEMBL9620801 | 0.81 | LMNA (0.51) | KDM4EMEN1MAPTKMT2ANPC1 | |
| SCHEMBL3922398 | 0.77 | APP (0.48) | KDM4EMEN1HSP90AA1MAPTCRHBP | |
| SCHEMBL3916255 | 0.76 | MAPT (0.60) | KDM4EMEN1HSP90AA1MAPTCRHBP | |
| SCHEMBL3916237 | 0.75 | PPARD (0.47) | KDM4EMEN1HSP90AA1MAPTCRHBP | |
| SCHEMBL6219017 | 0.74 | HDAC6 (0.48) | BACE1KDM4EMEN1HSP90AA1MAPT | |
| SCHEMBL3920688 | 0.74 | KDM4E (0.43) | KDM4EMEN1HSP90AA1MAPTCRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585726-A1 | FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063155-A1 | FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |