Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.44 |
| ▸ | PRNP | P04156 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27456891 | 0.79 | PSIP1 (0.48) | PSIP1HSD11B1ALDH1A1TP53HTT | |
| SCHEMBL20299659 | 0.78 | HSD11B1 (0.55) | PSIP1HSD11B1ALDH1A1TP53HTT | |
| SCHEMBL16015553 | 0.77 | PSIP1 (0.50) | PSIP1HSD11B1ALDH1A1TP53HTT | |
| SCHEMBL5469289 | 0.77 | SMN1; SMN2 (0.52) | PSIP1HSD11B1ALDH1A1TP53HTT | |
| SCHEMBL15062217 | 0.77 | SMN1; SMN2 (0.52) | PSIP1HSD11B1ALDH1A1TP53HTT | |
| SCHEMBL3245447 | 0.75 | SMN1; SMN2 (0.53) | PSIP1HSD11B1ALDH1A1TP53HTT | |
| SCHEMBL9043625 | 0.73 | SMN1; SMN2 (0.48) | PSIP1ALDH1A1TP53HTTHSD17B10 | |
| SCHEMBL9732594 | 0.73 | SMN1; SMN2 (0.48) | PSIP1HSD11B1ALDH1A1TP53HTT | |
| Acetic Acid SCHEMBL28112958 | 0.71 | PSIP1 (0.82) | PSIP1HSD11B1ALDH1A1TP53HTT | |
| SCHEMBL19392608 | 0.71 | ALDH1A1 (0.53) | PSIP1ALDH1A1TP53HTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575947-A1 | 2-OXOPYRIDIN-3-YL THIA(DI)AZOLE DERIVATIVES FOR USE IN THE TREATMENT OF CELL PROLIFERATION AND APOPTOSIS RELATED DISEASES | Amgen Inc. (US) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004060890-A1 | 2-OXOPYRIDIN-3-YL THIA (DI) AZOLE DERIVATES FOR USE IN THE TREATMENT OF CELL PROLIFERATION AND APOPTOSIS RELATED DISEASES | AMGEN INC. (US) | 2004-07-22 | — | — | WO | disclosed |