Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.69 |
| ▸ | NPC1 | O15118 | 6/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | F10 | P00742 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10495021 | 0.83 | NPC1 (0.77) | RAB9ANPC1SMN1; SMN2HPGDF10 | |
| SCHEMBL1578277 | 0.83 | NPC1 (1.00) | RAB9ANPC1SMN1; SMN2HPGDF10 | |
| SCHEMBL5014995 | 0.82 | MAOA (0.52) | RAB9ANPC1SMN1; SMN2POLBRECQL | |
| SCHEMBL528393 | 0.82 | MTNR1A (0.68) | POLBMAOBMAOALMNAALDH1A1 | |
| SCHEMBL4522403 | 0.81 | NPC1 (0.72) | RAB9ANPC1SMN1; SMN2HPGDF10 | |
| SCHEMBL11424416 | 0.80 | NPC1 (0.93) | RAB9ANPC1SMN1; SMN2HPGDF10 | |
| SCHEMBL11433155 | 0.80 | NPC1 (0.93) | RAB9ANPC1SMN1; SMN2HPGDF10 | |
| SCHEMBL527471 | 0.78 | MAOA (0.55) | RAB9ANPC1SMN1; SMN2HPGDMAOB | |
| SCHEMBL9059700 | 0.78 | MAOA (0.70) | RAB9ANPC1SMN1; SMN2POLBMAOB | |
| SCHEMBL2276760 | 0.78 | HPGD (0.56) | SMN1; SMN2HPGDKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171443-B1 | BICYCLIC HETEROAROMATIC COMPOUNDS USEFUL AS LH AGONISTS | AKZO NOBEL NV (NL) | 2005-07-13 | — | — | EP | disclosed |
| US-6841553-B2 | Bicyclic heteroaromatic compounds useful as LH agonists | AKZO NOBEL N.V. (NL) | 2005-01-11 | — | — | US | disclosed |
| US-20030212081-A1 | Bicyclic heteroaromatic compounds useful as LH agonists | MERCK SHARP & DOHME B.V. (NL) | 2003-11-13 | — | — | US | disclosed |
| US-6569863-B1 | Luteinizing hormone (LH) agonists for controlling fertility | AKZO NOBEL NV (NL) | 2003-05-27 | — | — | US | disclosed |
| EP-1171443-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS USEFUL AS LH AGONISTS | Akzo Nobel N.V. (NL) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000061586-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS USEFUL AS LH AGONISTS | AKZO NOBEL N.V. (NL) | 2000-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212081-A1 | Bicyclic heteroaromatic compounds useful as LH agonists | LHCGR, GNRHR, FSHR | RAB9A 3848/4885NPC1 1152/4885SMN1; SMN2 4821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.