SCHEMBL6220080

SCHEMBL6220080

CCOCc1nc2c(N)nc3cc(Br)cc(CCCOC)c3c2[nH]1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 1/20 0.33
TLR7 Q9NYK1 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4520810 0.83 TLR7 (0.34) TLR7
SCHEMBL18588106 0.73 TLR8 (0.42) TLR8TLR7
SCHEMBL30583610 0.73 TLR7 (0.47) TLR8TLR7
SCHEMBL4068898 0.71 TLR7 (0.34) TLR7
SCHEMBL5500726 0.71 DHFR (0.34) TLR8
SCHEMBL4654594 0.68 TLR7 (0.39) TLR8TLR7
SCHEMBL23421089 0.68 TLR8 (0.34) TLR8TLR7
SCHEMBL23421520 0.67 TLR8 (0.33) TLR8TLR7
SCHEMBL5513634 0.67 TLR7 (0.40) TLR8TLR7
SCHEMBL5508094 0.66 TLR8 (0.41) TLR8TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1590348-A1 ARYL / HETARYL SUBSTITUTED IMIDAZOQUINOLINES 3M Innovative Properties Company (US) 2005-11-02 EP disclosed
WO-2004058759-A1 ARYL / HETARYL SUBSTITUTED IMIDAZOQUINOLINES 3M INNOVATIVE PROPERTIES COMPANY (US) 2004-07-15 WO disclosed