Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.81 |
| ▸ | MAPT | P10636 | 4/20 | 0.81 |
| ▸ | RAB9A | P51151 | 3/20 | 0.81 |
| ▸ | NPC1 | O15118 | 2/20 | 0.81 |
| ▸ | GAA | P10253 | 1/20 | 0.81 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.81 |
| ▸ | ESR1 | P03372 | 1/20 | 0.64 |
| ▸ | SHBG | P04278 | 1/20 | 0.64 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2331741 | 0.90 | LMNA (1.00) | LMNAMAPTRAB9ANPC1GAA | |
| SCHEMBL29586883 | 0.90 | LMNA (0.67) | LMNAMAPTRAB9ANPC1GAA | |
| SCHEMBL30204024 | 0.90 | LMNA (1.00) | LMNAMAPTRAB9ANPC1GAA | |
| SCHEMBL17263407 | 0.82 | GAA (0.66) | LMNAMAPTRAB9ANPC1GAA | |
| SCHEMBL25666683 | 0.81 | MAPT (0.54) | LMNAMAPTRAB9ANPC1GAA | |
| SCHEMBL5266853 | 0.80 | LMNA (0.63) | LMNAMAPTRAB9ANPC1GAA | |
| SCHEMBL24939658 | 0.79 | MAPT (0.53) | LMNAMAPTRAB9ANPC1GAA | |
| SCHEMBL17740976 | 0.79 | LMNA (0.54) | LMNAMAPTRAB9ANPC1GAA | |
| SCHEMBL28566027 | 0.78 | LMNA (0.51) | LMNAMAPTRAB9ANPC1GAA | |
| SCHEMBL312243 | 0.78 | ESR1 (1.00) | LMNAMAPTRAB9ANPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| CN-1681763-A | Chemical compounds | ASTRAZENECA AB (SE) | 2005-10-12 | — | — | CN | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |