Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SHBG | P04278 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17429523 | 0.84 | LMNA (0.51) | LMNAMAPTNPC1RAB9AGAA | |
| SCHEMBL17429532 | 0.84 | MAPT (0.51) | LMNAMAPTNPC1RAB9AGAA | |
| SCHEMBL17429590 | 0.81 | MAPT (0.44) | LMNAMAPTNPC1RAB9AGAA | |
| SCHEMBL17740977 | 0.80 | ALOX15 (0.38) | LMNAMAPTNPC1RAB9AGAA | |
| SCHEMBL30253993 | 0.80 | ALOX15 (0.38) | LMNAMAPTNPC1RAB9AGAA | |
| SCHEMBL6220484 | 0.79 | LMNA (0.81) | LMNAMAPTNPC1RAB9AGAA | |
| SCHEMBL25666683 | 0.78 | MAPT (0.54) | LMNAMAPTNPC1RAB9AGAA | |
| SCHEMBL24939658 | 0.77 | MAPT (0.53) | LMNAMAPTNPC1RAB9AGAA | |
| SCHEMBL29586883 | 0.77 | LMNA (0.67) | LMNAMAPTNPC1RAB9AGAA | |
| SCHEMBL7534898 | 0.75 | HSP90AB1 (0.67) | LMNAMAPTNPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334926-A1 | PROCESS FOR PREPARING SUBSTITUTED INDOLE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2017-11-23 | — | — | US | disclosed |
| US-20170334926-A1 | PROCESS FOR PREPARING SUBSTITUTED INDOLE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2017-11-23 | — | — | US | disclosed |
| US-9725464-B2 | Process for preparing tetracyclic heterocycle compounds | MERCK SHARP & DOHME CORP. (US) | 2017-08-08 | — | — | US | disclosed |
| US-9725464-B2 | Process for preparing tetracyclic heterocycle compounds | MERCK SHARP & DOHME CORP. (US) | 2017-08-08 | — | — | US | disclosed |
| WO-2017097253-A1 | DEUTERIUM-MODIFIED ELBASVIR DERIVATIVE, DRUG COMPOSITION CONTAINING SAME, AND USE THEREOF | 正大天晴药业集团股份有限公司 | 2017-06-15 | — | — | WO | disclosed |
| US-20160257698-A1 | PROCESS FOR PREPARING TETRACYCLIC HETEROCYCLE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2016-09-08 | — | — | US | disclosed |
| US-20160257698-A1 | PROCESS FOR PREPARING TETRACYCLIC HETEROCYCLE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2016-09-08 | — | — | US | disclosed |
| WO-2016073659-A1 | PROCESS FOR PREPARING SUBSTITUTED INDOLE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2016-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334926-A1 | PROCESS FOR PREPARING SUBSTITUTED INDOLE COMPOUNDS | IDO1, IDO2, TPH1 | LMNA 4291/4885MAPT 2778/4885NPC1 1067/4885 |
| US-20160257698-A1 | PROCESS FOR PREPARING TETRACYCLIC HETEROCYCLE COMPOUNDS | GTF3C5, HCCS, GTF3C1 | LMNA 3490/4885MAPT 3829/4885NPC1 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.