Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.82 |
| ▸ | MAPT | P10636 | 4/20 | 0.82 |
| ▸ | MEN1 | O00255 | 4/20 | 0.82 |
| ▸ | POLB | P06746 | 2/20 | 0.82 |
| ▸ | NPC1 | O15118 | 2/20 | 0.82 |
| ▸ | RAB9A | P51151 | 2/20 | 0.82 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7229213 | 0.88 | MAPT (0.63) | KMT2AMAPTMEN1POLBNPC1 | |
| SCHEMBL8262647 | 0.86 | MAPT (0.77) | KMT2AMAPTMEN1POLBNPC1 | |
| SCHEMBL7229777 | 0.86 | MAPT (0.64) | KMT2AMAPTMEN1POLBNPC1 | |
| SCHEMBL28068499 | 0.80 | LMNA (0.60) | KMT2AMAPTMEN1POLBNPC1 | |
| SCHEMBL6201904 | 0.80 | MEN1 (0.74) | KMT2AMAPTMEN1POLBNPC1 | |
| SCHEMBL6709697 | 0.79 | KMT2A (0.54) | KMT2AMAPTMEN1POLBNPC1 | |
| SCHEMBL6707552 | 0.79 | KMT2A (0.58) | KMT2AMAPTMEN1POLBNPC1 | |
| SCHEMBL11632540 | 0.79 | MEN1 (0.49) | KMT2AMAPTMEN1POLBNPC1 | |
| SCHEMBL1791860 | 0.79 | MAPT (0.73) | KMT2AMAPTMEN1POLBNPC1 | |
| SCHEMBL6222740 | 0.79 | ALDH1A1 (0.54) | KMT2AMAPTMEN1POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |