Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.74 |
| ▸ | MAPT | P10636 | 4/20 | 0.74 |
| ▸ | NPC1 | O15118 | 3/20 | 0.74 |
| ▸ | RAB9A | P51151 | 3/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.69 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8066458 | 0.88 | ALDH1A1 (0.59) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL6222897 | 0.80 | KMT2A (0.82) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL1791860 | 0.79 | MAPT (0.73) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL5217880 | 0.76 | MAPT (0.63) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL10225886 | 0.75 | MAPT (0.71) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL28538184 | 0.75 | MMP8 (0.50) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL11575471 | 0.74 | KMT2A (0.66) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL8262647 | 0.74 | MAPT (0.77) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL2456224 | 0.74 | ALDH1A1 (0.64) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL14662953 | 0.74 | MAPT (0.69) | MEN1KMT2AMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |