Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ICMT | O60725 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6222183 | 0.82 | CARM1 (0.38) | CARM1ADRB2ALDH1A1KDM4E | |
| SCHEMBL5631471 | 0.75 | MAPT (0.53) | ADRB2CYP2D6ADRB1 | |
| SCHEMBL5631468 | 0.75 | MAPT (0.53) | ADRB2CYP2D6ADRB1 | |
| SCHEMBL12667923 | 0.68 | THRA (0.41) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL14572743 | 0.68 | MAPT (0.43) | ADRB2MEN1CYP2D6KMT2AADRA1A | |
| SCHEMBL5630902 | 0.67 | XDH (0.39) | ALDH1A1NPC1HPGDRAB9A | |
| SCHEMBL5630620 | 0.67 | XDH (0.39) | ALDH1A1NPC1HPGDRAB9A | |
| SCHEMBL9621528 | 0.66 | CYP1A2 (0.42) | SMN1; SMN2ALDH1A1MEN1CYP1A2CYP2D6 | |
| SCHEMBL17175976 | 0.66 | THRA (0.40) | SMN1; SMN2MEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL16726537 | 0.65 | CA2 (0.55) | ALDH1A1LMNAHPGDKDM4EADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565472-A2 | COMPOUNDS WITH MIXED PDE-INHIBITORY AND BETA-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITY FOR TREATMENT OF HEART FAILURE | Artesian Therapeutics, Inc. (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004050657-A2 | COMPOUNDS WITH MIXED PDE-INHIBITORY AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITY FOR TREATMENT OF HEART FAILURE | ARTESIAN THERAPEUTICS, INC. (US) | 2004-06-17 | — | — | WO | disclosed |