Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5553163 | 0.95 | SLC6A3 (0.47) | SLC6A3CYP2D6DPP4KCNH2OPRD1 | |
| SCHEMBL31647252 | 0.86 | OPRD1 (0.62) | SLC6A3CYP2D6DPP4KCNH2OPRD1 | |
| SCHEMBL16627319 | 0.86 | MC4R (0.61) | SLC6A3CYP2D6DPP4KCNH2OPRD1 | |
| SCHEMBL6448616 | 0.80 | DRD2 (0.45) | CYP2D6HRH3ALDH1A1CYP3A4USP2 | |
| SCHEMBL16982012 | 0.78 | CYP2D6 (0.56) | CYP2D6KCNH2OPRD1CHRM2CHRM1 | |
| SCHEMBL22227820 | 0.78 | CYP2D6 (0.47) | CYP2D6DPP4KCNH2OPRD1CHRM2 | |
| SCHEMBL20832769 | 0.78 | CYP2D6 (0.47) | CYP2D6DPP4KCNH2OPRD1CHRM2 | |
| SCHEMBL16270668 | 0.76 | CHRM2 (0.54) | SLC6A3CYP2D6HRH3CHRM2CHRM1 | |
| SCHEMBL2735673 | 0.76 | CHRM2 (0.54) | SLC6A3CYP2D6HRH3CHRM2CHRM1 | |
| SCHEMBL3576037 | 0.75 | CYP2D6 (0.52) | SLC6A3CYP2D6OPRD1CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110938076-B | Pyrrolopyrimidines as TLR7 agonists | 正大天晴药业集团股份有限公司 | 2021-08-10 | — | — | CN | disclosed |
| CN-112898308-A | Pyrrolopyrimidines as TLR7 agonists | 正大天晴药业集团股份有限公司 | 2021-06-04 | — | — | CN | disclosed |
| EP-3190113-B1 | PYRROLOPYRIMIDINE COMPOUNDS USED AS TLR7 AGONIST | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2021-05-19 | — | — | EP | disclosed |
| EP-3190113-B1 | PYRROLOPYRIMIDINE COMPOUNDS USED AS TLR7 AGONIST | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2021-05-19 | — | — | EP | disclosed |
| CN-110759916-B | Pyrrolopyrimidines as TLR7 agonists | 正大天晴药业集团股份有限公司 | 2021-02-19 | — | — | CN | disclosed |
| CN-110938076-A | Pyrrolopyrimidines as TLR7 agonists | 正大天晴药业集团股份有限公司 | 2020-03-31 | — | — | CN | disclosed |
| US-10555949-B2 | Pyrrolopyrimidine compounds used as TLR7 agonist | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2020-02-11 | — | — | US | disclosed |
| US-10555949-B2 | Pyrrolopyrimidine compounds used as TLR7 agonist | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2020-02-11 | — | — | US | disclosed |
| CN-110759916-A | Pyrrolopyrimidines as TLR7 agonists | 正大天晴药业集团股份有限公司 | 2020-02-07 | — | — | CN | disclosed |
| CN-106661034-B | Pyrrolopyrimidines as TLR7 agonists | 正大天晴药业集团股份有限公司 | 2019-11-29 | — | — | CN | disclosed |
| US-20170273983-A1 | PYRROLOPYRIMIDINE COMPOUNDS USED AS TLR7 AGONIST | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2017-09-28 | — | — | US | disclosed |
| US-20170273983-A1 | PYRROLOPYRIMIDINE COMPOUNDS USED AS TLR7 AGONIST | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2017-09-28 | — | — | US | disclosed |
| EP-3190113-A1 | PYRROLOPYRIMIDINE COMPOUNDS USED AS TLR7 AGONIST | Chai Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2017-07-12 | — | — | EP | disclosed |
| EP-3190113-A1 | PYRROLOPYRIMIDINE COMPOUNDS USED AS TLR7 AGONIST | Chai Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2017-07-12 | — | — | EP | disclosed |
| CN-106661034-A | Pyrrolopyrimidines as TLR7 agonists | 正大天晴药业集团股份有限公司 | 2017-05-10 | — | — | CN | disclosed |
| CN-105367576-A | Pyrrolopyrimidine compounds as TLR7 agonists | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD | 2016-03-02 | — | — | CN | disclosed |
| WO-2016023511-A1 | PYRROLOPYRIMIDINE COMPOUNDS USED AS TLR7 AGONIST | 正大天晴药业集团股份有限公司 | 2016-02-18 | — | — | WO | disclosed |
| EP-1534689-A1 | NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-06-01 | — | — | EP | disclosed |
| US-20040242572-A1 | New carboxamide compounds having melanin concentrating hormone antagonistic activity, pharmaceutical preparations comprising these compounds and process for their manufacture | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2004-12-02 | — | — | US | disclosed |
| WO-2004024702-A1 | NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242572-A1 | New carboxamide compounds having melanin concentrating hormone antagonistic activity, pharmaceutical preparations comprising these compounds and process for their manufacture | MCHR2, MCHR1, NPY1R | SLC6A3 1179/4885CYP2D6 1590/4885DPP4 550/4885 |
| US-10555949-B2 | Pyrrolopyrimidine compounds used as TLR7 agonist | TLR7, TLR9, TLR1 | SLC6A3 3777/4885CYP2D6 1307/4885DPP4 553/4885 |
| US-20170273983-A1 | PYRROLOPYRIMIDINE COMPOUNDS USED AS TLR7 AGONIST | TLR7, TLR9, TLR1 | SLC6A3 3777/4885CYP2D6 1307/4885DPP4 553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.