Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.48 |
| ▸ | KIF11 | P52732 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30108255 | 0.81 | CHUK (0.50) | TRPV1KIF11MEN1KMT2AIKBKB | |
| SCHEMBL5178386 | 0.77 | PARP1 (0.58) | KIF11LMNAPOLBMEN1GMNN | |
| SCHEMBL9002089 | 0.76 | NR2E1 (0.46) | TRPV1LMNAPOLBMEN1GMNN | |
| SCHEMBL5665026 | 0.75 | TRPV1 (0.52) | TRPV1PARP1 | |
| SCHEMBL6263085 | 0.74 | ALOX5AP (0.38) | TRPV1LMNAALDH1A1PTGS1PTGS2 | |
| SCHEMBL6263076 | 0.73 | PTGS1 (0.38) | TRPV1LMNAPOLBALDH1A1PTGS1 | |
| SCHEMBL2304391 | 0.71 | KDM4E (0.44) | MEN1ALDH1A1CYP3A4DHODHKMT2A | |
| SCHEMBL12054671 | 0.70 | KIF11 (0.59) | KIF11BRD4NPY5R | |
| SCHEMBL20475969 | 0.70 | ALDH1A1 (0.57) | LMNAMEN1ALDH1A1DHODHKMT2A | |
| SCHEMBL28777525 | 0.70 | LMNA (0.49) | LMNAALDH1A1TDP1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537084-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | Amgen Inc. (US) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004007458-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | AMGEN INC. (US) | 2004-01-22 | — | — | WO | disclosed |