SCHEMBL6225469

SCHEMBL6225469

O=C(NCCc1ccc(CN2CCC(Nc3ccccn3)CC2)cc1)Oc1ccc(-c2ccc(Cl)cc2)cc1[N+](=O)[O-]

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 3/20 0.46
FAAH O00519 3/20 0.46
BCHE P06276 2/20 0.46
AKT1 P31749 2/20 0.41
MCHR1 Q99705 6/20 0.41
DRD2 P14416 1/20 0.41
DRD4 P21917 1/20 0.41
DRD3 P35462 1/20 0.41
MAPK1 P28482 2/20 0.40
CHRM1 P11229 2/20 0.40
HTR2A P28223 2/20 0.40
CYP2D6 P10635 1/20 0.40
SIGMAR1 Q99720 2/20 0.40
MAPT P10636 1/20 0.40
PKM P14618 1/20 0.40
RAB9A P51151 1/20 0.40
BACE1 P56817 1/20 0.39
CXCR3 P49682 1/20 0.39
GPBAR1 Q8TDU6 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6222465 0.88 AKT1 (0.43) ACHEFAAHAKT1MCHR1DRD2
SCHEMBL6224533 0.88 FAAH (0.45) ACHEFAAHBCHEAKT1MCHR1
SCHEMBL6706734 0.87 NPC1 (0.51) AKT1MCHR1DRD2DRD4DRD3
SCHEMBL6228504 0.85 FAAH (0.49) ACHEFAAHBCHEMCHR1CHRM1
SCHEMBL6221960 0.84 MCHR1 (0.57) ACHEFAAHBCHEMCHR1CHRM1
SCHEMBL6224697 0.83 MCHR1 (0.57) ACHEFAAHBCHEMCHR1CHRM1
SCHEMBL6225433 0.82 FAAH (0.50) ACHEFAAHBCHEMCHR1DRD2
SCHEMBL6224439 0.80 FAAH (0.47) ACHEFAAHBCHEMCHR1DRD4
SCHEMBL6224507 0.79 MCHR1 (0.48) ACHEFAAHBCHEMCHR1CHRM1
SCHEMBL6705917 0.78 MCHR1 (0.54) AKT1MCHR1DRD2DRD4DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1534689-A1 NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2005-06-01 EP disclosed
WO-2004024702-A1 NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2004-03-25 WO disclosed