Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819003 | 0.86 | HTR2A (0.52) | KDM4EMEN1KMT2ASMN1; SMN2CYP2A6 | |
| SCHEMBL2239690 | 0.82 | MEN1 (0.49) | KDM4EMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL6569937 | 0.77 | TSHR (0.48) | KDM4EMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL167715 | 0.77 | AOC3 (0.55) | MEN1KMT2ATSHRSMN1; SMN2POLB | |
| SCHEMBL4785593 | 0.77 | TSHR (0.52) | KDM4EMEN1KMT2ATSHRSMN1; SMN2 | |
| Benzene SCHEMBL27914804 | 0.77 | AOC3 (0.55) | MEN1KMT2ATSHRSMN1; SMN2POLB | |
| SCHEMBL10697566 | 0.77 | TSHR (0.52) | KDM4EMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL4237177 | 0.77 | ALDH1A1 (0.48) | KDM4EMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL29187623 | 0.77 | ALDH1A1 (0.48) | KDM4EMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL19066702 | 0.76 | TAAR1 (0.56) | MEN1KMT2ASMN1; SMN2CYP2A6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411942-A4 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | SYNAPTIC PHARMA CORP (US) | 2005-01-26 | — | — | EP | disclosed |
| EP-1411942-A1 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | Synaptic Pharmaceutical Corporation (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003004027-A1 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2003-01-16 | — | — | WO | disclosed |