Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6225496 | 0.88 | CRHBP (0.54) | ABCB1SMN1; SMN2HTTMAPK1POLB | |
| SCHEMBL11316665 | 0.88 | KDM4E (0.57) | KDM4EGAAALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6225897 | 0.86 | ABCB1 (0.50) | ABCB1ALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL6224259 | 0.85 | SMN1; SMN2 (0.47) | ABCB1KDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6224090 | 0.85 | HSPB1 (0.47) | ABCB1GAAALDH1A1LMNAMAPT | |
| SCHEMBL6226144 | 0.82 | GRIN2D (0.41) | ABCB1KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL6224988 | 0.82 | MAPT (0.46) | ABCB1ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL6226629 | 0.81 | MAPT (0.43) | ABCB1LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL6225602 | 0.80 | ABCB1 (0.50) | ABCB1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6225779 | 0.77 | MCL1 (0.54) | ABCB1ALDH1A1SMN1; SMN2MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534689-A1 | NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004024702-A1 | NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-03-25 | — | — | WO | disclosed |