Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6225602 | 0.88 | ABCB1 (0.50) | ABCB1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL6225781 | 0.86 | ABCB1 (0.46) | ABCB1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL6225496 | 0.85 | CRHBP (0.54) | ABCB1SMN1; SMN2MAPK1ABCC1HTT | |
| SCHEMBL12312144 | 0.85 | PDGFRB (0.57) | ABCB1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL6224090 | 0.83 | HSPB1 (0.47) | ABCB1MAPTALDH1A1LMNAABCC1 | |
| SCHEMBL6224259 | 0.83 | SMN1; SMN2 (0.47) | ABCB1SMN1; SMN2MAPTHPGDALDH1A1 | |
| SCHEMBL377359 | 0.81 | MAPT (0.42) | SMN1; SMN2NPC1RAB9AMAPTHPGD | |
| SCHEMBL3036336 | 0.80 | ALDH1A1 (0.42) | SMN1; SMN2NPC1RAB9AMAPTHPGD | |
| SCHEMBL5194932 | 0.80 | ABCB1 (0.52) | ABCB1SMN1; SMN2MAPTHPGDALDH1A1 | |
| SCHEMBL11200639 | 0.80 | ALDH1A1 (0.52) | NPC1RAB9AMAPTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534689-A1 | NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004024702-A1 | NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-03-25 | — | — | WO | disclosed |