Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6224259 | 0.87 | SMN1; SMN2 (0.47) | MAPTLMNAMEN1KMT2AABCB1 | |
| SCHEMBL6225496 | 0.84 | CRHBP (0.54) | ABCB1POLBSMN1; SMN2 | |
| SCHEMBL6225781 | 0.81 | ABCB1 (0.46) | MAPTLMNAKMT2AABCB1POLB | |
| SCHEMBL6224090 | 0.81 | HSPB1 (0.47) | MAPTLMNAMEN1KMT2AABCB1 | |
| SCHEMBL6225897 | 0.79 | ABCB1 (0.50) | MAPTLMNAMEN1KMT2AABCB1 | |
| SCHEMBL6224988 | 0.78 | MAPT (0.46) | MAPTLMNAMEN1KMT2AABCB1 | |
| SCHEMBL6226144 | 0.78 | GRIN2D (0.41) | MAPTMEN1KMT2AABCB1POLB | |
| SCHEMBL6226628 | 0.78 | EIF4E (0.48) | MAPTVCAM1MEN1KMT2AHSD17B10 | |
| SCHEMBL6225602 | 0.76 | ABCB1 (0.50) | MAPTABCB1TDP1SMN1; SMN2 | |
| Nornitrogen Mustard SCHEMBL4942596 | 0.76 | ABCB1 (0.50) | MAPTABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534689-A1 | NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004024702-A1 | NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-03-25 | — | — | WO | disclosed |