Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | AR | P10275 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15389443 | 0.87 | TSHR (0.46) | TSHRARMAPTALDH1A1KDM4E | |
| SCHEMBL7760077 | 0.79 | TSHR (0.50) | TSHRARTDP1MEN1MAPT | |
| SCHEMBL30950444 | 0.78 | DYRK1A (0.41) | TSHRARALDH1A1KDM4ECYP1A2 | |
| SCHEMBL26552130 | 0.78 | TSHR (0.39) | TSHRARTDP1ALDH1A1KDM4E | |
| SCHEMBL4460481 | 0.77 | CYP2A6 (0.45) | TSHRTDP1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL31527965 | 0.74 | TSHR (0.38) | TSHRARALDH1A1SMN1; SMN2 | |
| SCHEMBL31287953 | 0.73 | MAOA (0.51) | TSHRTDP1MEN1MAPTKMT2A | |
| SCHEMBL29941499 | 0.73 | TSHR (0.65) | TSHRARTDP1MEN1MAPT | |
| SCHEMBL21022697 | 0.73 | TSHR (0.65) | TSHRARALDH1A1KDM4ECYP1A2 | |
| SCHEMBL102574 | 0.73 | TSHR (0.65) | TSHRARTDP1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1081141-B1 | Method for producing 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS (JP) | 2005-05-04 | — | — | EP | claimed |
| EP-1081141-A1 | Method for producing 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2001-03-07 | — | — | EP | claimed |
| EP-0702008-A2 | Method for producing 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1996-03-20 | — | — | EP | claimed |
| US-8802862-B2 | 1,2-benzisothiazol-3-one compound production method | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2014-08-12 | — | — | US | disclosed |
| EP-2687520-A1 | METHOD FOR PRODUCING 1,2-BENZISOTHIAZOL-3-ONE COMPOUND | Sumitomo Seika Chemicals Co., Ltd. (JP) | 2014-01-22 | — | — | EP | disclosed |
| EP-2687519-A1 | 1,2-BENZISOTHIAZOL-3-ONE COMPOUND PRODUCTION METHOD | Sumitomo Seika Chemicals CO. LTD. (JP) | 2014-01-22 | — | — | EP | disclosed |
| US-20130345434-A1 | METHOD FOR PRODUCING 1,2-BENZISOTHIAZOL-3-ONE COMPOUND | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2013-12-26 | — | — | US | disclosed |
| US-20130345433-A1 | 1,2-BENZISOTHIAZOL-3-ONE COMPOUND PRODUCTION METHOD | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2013-12-26 | — | — | US | disclosed |
| EP-1081141-B1 | Method for producing 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS (JP) | 2005-05-04 | — | — | EP | disclosed |
| EP-1081141-A1 | Method for producing 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2001-03-07 | — | — | EP | disclosed |
| US-5773626-A | HALOGENATION OF A 2-(ALKYLTHIO)BENZALDEHYDE OXIME | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1998-06-30 | — | — | US | disclosed |
| US-5633384-A | FROM O-ALKYLTHIOBENZONITRILES | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1997-05-27 | — | — | US | disclosed |
| EP-0702008-A2 | Method for producing 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1996-03-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130345434-A1 | METHOD FOR PRODUCING 1,2-BENZISOTHIAZOL-3-ONE COMPOUND | TST, SOAT1, BZW2 | TSHR 2160/4885AR 2824/4885TDP1 3329/4885 |
| US-20130345433-A1 | 1,2-BENZISOTHIAZOL-3-ONE COMPOUND PRODUCTION METHOD | BZW1, BZW2, NAT1 | TSHR 2656/4885AR 2782/4885TDP1 2358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.