Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | CTSG | P08311 | 1/20 | 0.41 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12121920 | 0.85 | POLB (0.66) | POLBNPSR1PIN1MMP8ALDH1A1 | |
| SCHEMBL5885245 | 0.81 | ALDH1A1 (0.50) | POLBNPSR1PIN1MMP8ALDH1A1 | |
| SCHEMBL21768348 | 0.75 | TDP1 (0.58) | POLBNPSR1PIN1NPC1MEN1 | |
| SCHEMBL18113289 | 0.74 | POLB (0.46) | POLBNPSR1PIN1MMP8ALDH1A1 | |
| SCHEMBL164403 | 0.74 | POLB (0.49) | POLBNPSR1PIN1MMP8ALDH1A1 | |
| SCHEMBL8697207 | 0.73 | SMN1; SMN2 (0.49) | POLBALDH1A1MAPTNPC1MEN1 | |
| SCHEMBL9437333 | 0.73 | MEN1 (0.51) | POLBNPSR1PIN1MMP8ALDH1A1 | |
| SCHEMBL1492859 | 0.73 | MMP8 (0.65) | POLBNPSR1PIN1MMP8ALDH1A1 | |
| SCHEMBL4621876 | 0.73 | PIN1 (0.51) | POLBNPSR1PIN1MMP8ALDH1A1 | |
| SCHEMBL6932564 | 0.72 | POLB (0.54) | POLBNPSR1PIN1MMP8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1525177-A1 | SUBSTITUTED 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVES AND PREPARATION AND USES THEREOF | Genfit (FR) | 2005-04-27 | — | — | EP | disclosed |
| WO-2004005233-A1 | SUBSTITUTED 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVES AND PREPARATION AND USES THEREOF | GENFIT (FR) | 2004-01-15 | — | — | WO | disclosed |