Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 3/20 | 0.31 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 3/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.30 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624426 | 0.85 | MAPT (0.41) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL623258 | 0.77 | MAPT (0.43) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL624101 | 0.74 | MAPT (0.46) | MAPTALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL622511 | 0.70 | NR1H2 (0.36) | MAPTALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL14261377 | 0.66 | ALDH1A1 (0.54) | MAPTALDH1A1MAPK1HSD17B10HPGD | |
| SCHEMBL623301 | 0.64 | MAPT (0.49) | MAPTALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL27270422 | 0.63 | MEN1 (0.41) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL623383 | 0.61 | MAPT (0.52) | MAPTALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL3615750 | 0.58 | MAPT (0.62) | MAPTALDH1A1KMT2AHPGDKDM4E | |
| SCHEMBL6206616 | 0.56 | ALDH1A1 (0.54) | MAPTALDH1A1MEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020227-A1 | TRICYCLIC COMPOUNDS FOR USE AS KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |