Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10585273 | 0.72 | ALDH1A1 (0.43) | TDP1ALDH1A1PARP1MAPTKDM4E | |
| SCHEMBL9455748 | 0.72 | ALDH1A1 (0.50) | TDP1ALDH1A1PARP1MAPTKDM4E | |
| SCHEMBL28027350 | 0.71 | TDP1 (0.73) | TDP1ALDH1A1PARP1MAPTKDM4E | |
| SCHEMBL20022717 | 0.71 | KDM4E (0.48) | ALDH1A1PARP1MAPTKDM4EMAPK1 | |
| SCHEMBL1412268 | 0.71 | ALDH1A1 (0.48) | ALDH1A1PARP1MAPTKDM4EDDAH1 | |
| SCHEMBL6232605 | 0.71 | ALDH1A1 (0.48) | ALDH1A1PARP1MAPTKDM4ECYP1A2 | |
| SCHEMBL29475175 | 0.70 | TDP1 (1.00) | TDP1ALDH1A1PARP1NOS1CYP3A4 | |
| SCHEMBL57166 | 0.70 | TDP1 (1.00) | TDP1ALDH1A1PARP1NOS1CYP3A4 | |
| SCHEMBL29804662 | 0.69 | TDP1 (0.52) | TDP1ALDH1A1PARP1MAPTKDM4E | |
| SCHEMBL28093598 | 0.68 | TDP1 (0.95) | TDP1ALDH1A1PARP1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8664404-B2 | Method for producing 3-halo-1,2-benzisothiazoles | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2014-03-04 | — | — | US | claimed |
| WO-2015055293-A1 | METHOD FOR THE PREPARATION OF 1,2-BENZISOTHIAZOLIN-3-ONES | THOR GMBH (DE) | 2015-04-23 | — | — | WO | disclosed |
| EP-2554543-B1 | METHOD FOR PRODUCING 3-HALO-1,2-BENZISOTHIAZOLES | SUMITOMO SEIKA CHEMICALS (JP) | 2015-01-21 | — | — | EP | disclosed |
| US-8802862-B2 | 1,2-benzisothiazol-3-one compound production method | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2014-08-12 | — | — | US | disclosed |
| US-8664404-B2 | Method for producing 3-halo-1,2-benzisothiazoles | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2014-03-04 | — | — | US | disclosed |
| EP-2687520-A1 | METHOD FOR PRODUCING 1,2-BENZISOTHIAZOL-3-ONE COMPOUND | Sumitomo Seika Chemicals Co., Ltd. (JP) | 2014-01-22 | — | — | EP | disclosed |
| EP-2687519-A1 | 1,2-BENZISOTHIAZOL-3-ONE COMPOUND PRODUCTION METHOD | Sumitomo Seika Chemicals CO. LTD. (JP) | 2014-01-22 | — | — | EP | disclosed |
| US-20130345433-A1 | 1,2-BENZISOTHIAZOL-3-ONE COMPOUND PRODUCTION METHOD | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2013-12-26 | — | — | US | disclosed |
| US-20130345434-A1 | METHOD FOR PRODUCING 1,2-BENZISOTHIAZOL-3-ONE COMPOUND | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2013-12-26 | — | — | US | disclosed |
| EP-2554543-A1 | METHOD FOR PRODUCING 3-HALO-1,2-BENZISOTHIAZOLES | Sumitomo Seika Chemicals Co., Ltd. (JP) | 2013-02-06 | — | — | EP | disclosed |
| US-20130005983-A1 | METHOD FOR PRODUCING 3-HALO-1,2-BENZISOTHIAZOLES | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2013-01-03 | — | — | US | disclosed |
| EP-1081141-B1 | Method for producing 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS (JP) | 2005-05-04 | — | — | EP | disclosed |
| EP-0702008-B1 | Method for producing 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS (JP) | 2001-08-29 | — | — | EP | disclosed |
| EP-1081141-A1 | Method for producing 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2001-03-07 | — | — | EP | disclosed |
| US-5773626-A | HALOGENATION OF A 2-(ALKYLTHIO)BENZALDEHYDE OXIME | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1998-06-30 | — | — | US | disclosed |
| US-5633384-A | FROM O-ALKYLTHIOBENZONITRILES | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1997-05-27 | — | — | US | disclosed |
| EP-0702008-A2 | Method for producing 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1996-03-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130005983-A1 | METHOD FOR PRODUCING 3-HALO-1,2-BENZISOTHIAZOLES | NAT1, BPNT1, CBR1 | TDP1 1766/4885ALDH1A1 88/4885PARP1 3771/4885 |
| US-20130345434-A1 | METHOD FOR PRODUCING 1,2-BENZISOTHIAZOL-3-ONE COMPOUND | TST, SOAT1, BZW2 | TDP1 3329/4885ALDH1A1 81/4885PARP1 1434/4885 |
| US-20130345433-A1 | 1,2-BENZISOTHIAZOL-3-ONE COMPOUND PRODUCTION METHOD | BZW1, BZW2, NAT1 | TDP1 2358/4885ALDH1A1 598/4885PARP1 544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.