Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.48 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | MIF | P14174 | 3/20 | 0.38 |
| ▸ | DAO | P14920 | 3/20 | 0.36 |
| ▸ | DDO | Q99489 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9455748 | 0.78 | ALDH1A1 (0.50) | ALDH1A1LMNAMAPTKDM4EDDAH1 | |
| SCHEMBL20022717 | 0.76 | KDM4E (0.48) | ALDH1A1LMNAMAPTKDM4EDDAH1 | |
| SCHEMBL31287951 | 0.76 | ALDH1A1 (0.47) | ALDH1A1LMNAMAPTKDM4EDDAH1 | |
| SCHEMBL6232605 | 0.76 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPTKDM4EDDAH1 | |
| SCHEMBL20022719 | 0.76 | KDM4E (0.48) | ALDH1A1LMNAMAPTKDM4EDDAH1 | |
| SCHEMBL31287980 | 0.72 | ALDH1A1 (0.47) | ALDH1A1LMNAMAPTKDM4EDDAH1 | |
| SCHEMBL292306 | 0.72 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPTKDM4EDDAH1 | |
| SCHEMBL31288017 | 0.72 | CA1 (0.44) | ALDH1A1LMNAMAPTKDM4EDDAH1 | |
| SCHEMBL31287982 | 0.71 | ALDH1A1 (0.37) | ALDH1A1LMNAMAPTKDM4EDDAH1 | |
| SCHEMBL1710671 | 0.68 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPTKDM4EDDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024259250-A2 | 5-HT2A RECEPTOR MODULATORS AND METHODS OF USE THEREOF | Transneural Therapeutics, Inc. (US) | 2024-12-19 | — | — | WO | disclosed |
| US-20220380383-A1 | NEUROPROTECTIVE PDI MODULATING SMALL MOLECULES AND METHODS OF USE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2022-12-01 | — | — | US | disclosed |
| WO-2020113222-A1 | NEUROPROTECTIVE PDI MODULATING SMALL MOLECULES AND METHODS OF USE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-06-04 | — | — | WO | disclosed |
| US-20180092908-A1 | SMALL MOLECULE OXIDIZERS OF PDI AND THEIR USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2018-04-05 | — | — | US | disclosed |
| US-20180092908-A1 | SMALL MOLECULE OXIDIZERS OF PDI AND THEIR USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2018-04-05 | — | — | US | disclosed |
| US-9662328-B2 | Targeting human thymidylate kinase induces DNA repair toxicity in malignant tumor cells | NATIONAL TAIWAN UNIVERSITY (TW) | 2017-05-30 | — | — | US | disclosed |
| US-20160151362-A1 | TARGETING HUMAN THYMIDYLATE KINASE INDUCES DNA REPAIR TOXICITY IN MALIGNANT TUMOR CELLS | NATIONAL TAIWAN UNIVERSITY (TW) | 2016-06-02 | — | — | US | disclosed |
| EP-2294059-A1 | 3-AMINO-BENZO [D]ISOTHIAZOLE DIOXIDE DERIVATIVES AND THEIR USE AS PESTICIDES | Syngenta Participations AG (CH) | 2011-03-16 | — | — | EP | disclosed |
| WO-2009141305-A1 | 3-AMINO-BENZO [D] ISOTHIAZOLE DIOXIDE DERIVATIVES AND THEIR USE AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160151362-A1 | TARGETING HUMAN THYMIDYLATE KINASE INDUCES DNA REPAIR TOXICITY IN MALIGNANT TUMOR CELLS | DTYMK, TYMP, TK1 | ALDH1A1 1743/4885LMNA 4164/4885MAPT 2559/4885 |
| US-20220380383-A1 | NEUROPROTECTIVE PDI MODULATING SMALL MOLECULES AND METHODS OF USE THEREOF | NLN, PDIA5, PRNP | ALDH1A1 1160/4885LMNA 1545/4885MAPT 99/4885 |
| US-20180092908-A1 | SMALL MOLECULE OXIDIZERS OF PDI AND THEIR USE | PDIA5, PDIA4, PDIA6 | ALDH1A1 1489/4885LMNA 4331/4885MAPT 183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.