Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.46 |
| ▸ | CLK2 | P49760 | 2/20 | 0.46 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.46 |
| ▸ | MARK3 | P27448 | 1/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | NEK4 | P51957 | 1/20 | 0.46 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6230911 | 0.93 | MAPT (0.50) | IRAK4PKMALDH1A1MAPTPOLB | |
| SCHEMBL6231609 | 0.84 | KMT2A (0.51) | IRAK4MAP4K4CSNK1DCLK2IRAK1 | |
| SCHEMBL6277473 | 0.83 | MAPT (0.47) | IRAK4MAP4K4CSNK1DCLK2IRAK1 | |
| SCHEMBL6231081 | 0.80 | CFTR (0.47) | IRAK4PKMALDH1A1MAPTKMT2A | |
| SCHEMBL6265827 | 0.79 | OPRM1 (0.42) | IRAK4PKMALDH1A1MAPTKMT2A | |
| SCHEMBL17487374 | 0.77 | MAPT (0.53) | PKMMAPTPOLBKMT2AMEN1 | |
| SCHEMBL6275418 | 0.72 | RAB9A (0.47) | IRAK4ALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL24900462 | 0.72 | MAPT (0.55) | IRAK4PKMALDH1A1MAPTPOLB | |
| SCHEMBL17487406 | 0.68 | MAPT (0.51) | PKMALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL9213942 | 0.68 | KDM4E (0.71) | IRAK4PKMALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004092181-A9 | HETEROCYCLIC MCHR1 ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-01-27 | — | — | WO | disclosed |