Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.36 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.33 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6271807 | 0.90 | EGFR (0.39) | EGFRERBB2PIP4K2APIP4K2CLMNA | |
| SCHEMBL6234112 | 0.85 | ALDH1A1 (0.41) | EGFRERBB2PIP4K2APIP4K2CALDH1A1 | |
| SCHEMBL6269171 | 0.84 | EGFR (0.41) | EGFRERBB2ALDH1A1MAPTERBB4 | |
| Formic Acid SCHEMBL6256978 | 0.83 | EGFR (0.46) | EGFRERBB2ERBB4 | |
| Formic Acid SCHEMBL6256982 | 0.83 | EGFR (0.46) | EGFRERBB2ERBB4 | |
| SCHEMBL6271804 | 0.77 | EGFR (0.52) | EGFRERBB2ERBB4 | |
| SCHEMBL6271801 | 0.77 | EGFR (0.52) | EGFRERBB2ERBB4 | |
| SCHEMBL6269168 | 0.70 | EGFR (0.54) | EGFRERBB2ERBB4 | |
| SCHEMBL6235814 | 0.69 | EGFR (0.49) | EGFRPIP4K2APIP4K2CALDH1A1TDP1 | |
| SCHEMBL6239978 | 0.69 | EGFR (0.47) | EGFRERBB2ERBB4FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007083-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-27 | — | — | WO | claimed |
| WO-2005007083-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-27 | — | — | WO | disclosed |