Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | ILK | Q13418 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235809 | 0.82 | EGFR (0.50) | EGFRSCN9AKDRALDH1A1LMNA | |
| SCHEMBL6235826 | 0.82 | EGFR (0.50) | EGFRSCN9AKDRALDH1A1LMNA | |
| SCHEMBL6234112 | 0.73 | ALDH1A1 (0.41) | EGFRALDH1A1PIP4K2APIP4K2CTSHR | |
| SCHEMBL6239978 | 0.71 | EGFR (0.47) | EGFR | |
| SCHEMBL6269171 | 0.71 | EGFR (0.41) | EGFRKDRALDH1A1MEN1KMT2A | |
| SCHEMBL6236027 | 0.71 | EGFR (0.47) | EGFR | |
| Hydrochloric Acid SCHEMBL8812502 | 0.70 | HSD17B10 (0.69) | EGFRKDRALDH1A1LMNAKDM4E | |
| SCHEMBL6271807 | 0.69 | EGFR (0.39) | EGFRLMNAPIP4K2APIP4K2C | |
| SCHEMBL6233688 | 0.69 | EGFR (0.36) | EGFRALDH1A1LMNAKDM4ETDP1 | |
| SCHEMBL6252739 | 0.68 | EGFR (0.42) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007083-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-27 | — | — | WO | claimed |
| WO-2005007083-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-27 | — | — | WO | disclosed |