Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 13/20 | 0.39 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.35 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.35 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6233688 | 0.90 | EGFR (0.36) | EGFRERBB2ERBB4PIP4K2APIP4K2C | |
| SCHEMBL6271804 | 0.86 | EGFR (0.52) | EGFRERBB2ERBB4 | |
| SCHEMBL6271801 | 0.86 | EGFR (0.52) | EGFRERBB2ERBB4 | |
| SCHEMBL6234112 | 0.86 | ALDH1A1 (0.41) | EGFRERBB2PIP4K2APIP4K2CMKNK1 | |
| SCHEMBL6269171 | 0.84 | EGFR (0.41) | EGFRERBB2ERBB4MAPT | |
| Formic Acid SCHEMBL6256982 | 0.74 | EGFR (0.46) | EGFRERBB2ERBB4 | |
| Formic Acid SCHEMBL6256978 | 0.74 | EGFR (0.46) | EGFRERBB2ERBB4 | |
| SCHEMBL6236350 | 0.72 | FLT1 (0.49) | EGFRERBB2 | |
| SCHEMBL6269166 | 0.70 | EGFR (0.54) | EGFRERBB2ERBB4 | |
| SCHEMBL6269168 | 0.70 | EGFR (0.54) | EGFRERBB2ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007083-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-27 | — | — | WO | claimed |