Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6230997 | 1.00 | MCHR1 (0.49) | MCHR1MAPTHTR2CSIGMAR1HTR3E | |
| SCHEMBL5766028 | 0.89 | TRPV6 (0.49) | MCHR1MAPTSIGMAR1HTR3EHTR3B | |
| SCHEMBL6255250 | 0.89 | MCHR1 (0.52) | MCHR1HTR3EHTR3BALDH1A1CYP1A2 | |
| SCHEMBL6234327 | 0.81 | MCHR1 (0.51) | MCHR1MAPTHTR2CALDH1A1CYP3A4 | |
| SCHEMBL6232220 | 0.81 | ALDH1A1 (0.53) | MCHR1HTR2CHTR3EHTR3BALDH1A1 | |
| SCHEMBL6230633 | 0.80 | ALDH1A1 (0.55) | MCHR1HTR2CHTR3EHTR3BALDH1A1 | |
| SCHEMBL6231556 | 0.78 | HTR1A (0.51) | MCHR1MAPTHTR3EHTR3BALDH1A1 | |
| SCHEMBL6232309 | 0.78 | CTSB (0.55) | MCHR1MAPTHTR3EHTR3BALDH1A1 | |
| SCHEMBL10365458 | 0.76 | ALDH1A1 (0.46) | HTR3EHTR3BALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL6231291 | 0.74 | ALDH1A1 (0.53) | MCHR1HTR3EHTR3BALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004092181-A9 | HETEROCYCLIC MCHR1 ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-01-27 | — | — | WO | disclosed |