Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.49 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.47 |
| ▸ | SMO | Q99835 | 5/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | DRD3 | P35462 | 4/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235873 | 0.86 | DRD3 (0.50) | DRD2DRD3KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL6242596 | 0.85 | PANK3 (0.46) | PANK3PDE3AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL2224211 | 0.79 | MAP4K4 (0.50) | SMORETKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL29462081 | 0.79 | RET (0.48) | PANK3SMORETKDM4EALDH1A1 | |
| SCHEMBL6259732 | 0.78 | GPR119 (0.50) | PANK3SMOKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL14349592 | 0.77 | EGLN2 (0.53) | PANK3SMORETDRD2KDM4E | |
| SCHEMBL29514660 | 0.76 | KDM4E (0.54) | PANK3SMOKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL3048925 | 0.76 | KDM4E (0.54) | PANK3SMOKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL14844043 | 0.76 | SMO (0.56) | PANK3SMOKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL21135514 | 0.76 | MAP4K4 (0.52) | PANK3SMOKDM4EALDH1A1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |